Anti-SRSF10 Antibody (CAB6024)
- SKU:
- CAB6024
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- SRSF10
- Synonyms:
- FUSIP1
- Synonyms:
- FUSIP2
- Synonyms:
- NSSR
- Synonyms:
- PPP1R149
- Synonyms:
- SFRS13
- Synonyms:
- SFRS13A
- Synonyms:
- SRp38
- Synonyms:
- SRrp40
- Synonyms:
- TASR
- Synonyms:
- TASR1
- Synonyms:
- TASR2
Description
| Product Name: | SRSF10 Rabbit pAb |
| Product Code: | CAB6024 |
| Size: | 50uL, 100uL |
| Synonyms: | SRSF10, FUSIP1, FUSIP2, NSSR, PPP1R149, SFRS13, SFRS13A, SRp38, SRrp40, TASR, TASR1, TASR2 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human SRSF10. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, 22Rv1, K-562, C2C12, Mouse testis, Rat testis |
| Immunogen: | Recombinant protein of human SRSF10. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10772 |
| Uniprot: | O75494 |
| Cellular Location: | Cytoplasm, Nucleus speckle |
| Calculated MW: | 20kDa/21kDa/22kDa/31kDa |
| Observed MW: | 40KDa |
| UniProt Protein Function: | SRSF10: Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator. Belongs to the splicing factor SR family. 5 isoforms of the human protein are produced by alternative splicing. Protein type: RNA-binding; RNA splicing Chromosomal Location of Human Ortholog: 1p36.11 Cellular Component: nuclear speck; nucleoplasm; nucleus Molecular Function: protein binding; RNA binding Biological Process: mRNA splice site selection; negative regulation of nuclear mRNA splicing, via spliceosome; nuclear mRNA splicing, via spliceosome; regulation of nuclear mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions |
| UniProt Protein Details: | |
| NCBI Summary: | This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| UniProt Code: | O75494 |
| NCBI GenInfo Identifier: | 47605579 |
| NCBI Gene ID: | 10772 |
| NCBI Accession: | O75494.1 |
| UniProt Secondary Accession: | O75494,O60572, Q5JRH9, Q5JRI0, Q5JRI2, Q5JRI3, Q5JRI4 Q96G09, A6NFM6, A6NI42 |
| UniProt Related Accession: | O75494 |
| Molecular Weight: | 22,135 Da |
| NCBI Full Name: | Serine/arginine-rich splicing factor 10 |
| NCBI Synonym Full Names: | serine and arginine rich splicing factor 10 |
| NCBI Official Symbol: | SRSF10 |
| NCBI Official Synonym Symbols: | NSSR; TASR; SRp38; TASR1; TASR2; FUSIP1; FUSIP2; SFRS13; SRrp40; SFRS13A; PPP1R149 |
| NCBI Protein Information: | serine/arginine-rich splicing factor 10 |
| UniProt Protein Name: | Serine/arginine-rich splicing factor 10 |
| UniProt Synonym Protein Names: | 40 kDa SR-repressor protein; SRrp40; FUS-interacting serine-arginine-rich protein 1; Splicing factor SRp38; Splicing factor, arginine/serine-rich 13A; TLS-associated protein with Ser-Arg repeats; TASR; TLS-associated protein with SR repeats; TLS-associated serine-arginine protein; TLS-associated SR protein |
| Protein Family: | Serine/arginine-rich splicing factor |
| UniProt Gene Name: | SRSF10 |
| UniProt Entry Name: | SRS10_HUMAN |
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