Cell Biology Antibodies 15

Anti-SRRT Antibody (CAB8219)

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SKU:
CAB8219
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody

Description

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Antibody Name:Anti-SRRT Antibody
Antibody SKU:CAB8219
Antibody Size:20uL, 50uL, 100uL
Application:IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 623-872 of human SRRT (NP_001122325.1).
Application:IHC
Recommended Dilution:IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 623-872 of human SRRT (NP_001122325.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DYYN TCEY PNED EMPN RCGI IHVR GPMP PNRI SHGE VLEW QKTF EEKL TPLL SVRE SLSE EEAQ KMGR KDPE QEVE KFVT SNTQ ELGK DKWL CPLS GKKF KGPE FVRK HIFN KHAE KIEE VKKE VAFF NNFL TDAK RPAL PEIK PAQP PGPA QSLT PGLP YPHQ TPQG LMPY GQPR PPIL GYGA GAVR PAVP TGGP PYPH APYG AGRG NYDA FRGQ GGYP GKPR NRMV RGDP RAIV EYRD LDAP DDVD FF
Gene ID:51593
Uniprot:Q9BXP5
Cellular Location:Cytoplasm, Nucleus, nucleoplasm
Calculated MW:96kDa/100kDa
Observed MW:Refer to figures
Synonyms:SRRT, ARS2, ASR2, serrate
Background:
UniProt Protein Function:SRRT: Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription. Belongs to the ARS2 family. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:RNA-binding; RNA processing; Spliceosome

Chromosomal Location of Human Ortholog: 7q21

Cellular Component: cytoplasm; nucleoplasm

Molecular Function:DNA binding; protein binding

Biological Process: cell proliferation; nuclear mRNA splicing, via spliceosome; primary microRNA processing; regulation of transcription, DNA-dependent; snRNA transcription from RNA polymerase II promoter

UniProt Code:Q9BXP5
NCBI GenInfo Identifier:20137457
NCBI Gene ID:51593
NCBI Accession:Q9BXP5.1
UniProt Secondary Accession:Q9BXP5,O95808, Q32MI4, Q6NT74, Q8TDQ5, Q9BWP6, Q9BXP4 A4D2E5, A4D2E6, A6NK22, B4DJL4, B4DZA6,
UniProt Related Accession:Q9BXP5
Molecular Weight:96,222 Da
NCBI Full Name:Serrate RNA effector molecule homolog
NCBI Synonym Full Names:serrate, RNA effector molecule
NCBI Official Symbol:SRRT  
NCBI Official Synonym Symbols:ARS2; ASR2; serrate  
NCBI Protein Information:serrate RNA effector molecule homolog
UniProt Protein Name:Serrate RNA effector molecule homolog
UniProt Synonym Protein Names:Arsenite-resistance protein 2
UniProt Gene Name:SRRT  
UniProt Entry Name:SRRT_HUMAN
Anti-SRRT Antibody (CAB8219)Immunohistochemistry - SRRT Polyclonal Antibody (CAB8219)
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