Epigenetics & Nuclear Signaling Antibodies 2
Anti-SRRM1 Antibody (CAB6066)
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- SKU:
- CAB6066
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-SRRM1 Antibody |
| Antibody SKU: | CAB6066 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human SRRM1 (NP_005830.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HT-29, OVCAR3, LO2, HeLa, Jurkat, Mouse liver, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human SRRM1 (NP_005830.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDAG FFRG TSAE QDNR FSNK QKKL LKQL KFAE CLEK KVDM SKVN LEVI KPWI TKRV TEIL GFED DVVI EFIF NQLE VKNP DSKM MQIN LTGF LNGK NARE FMGE LWPL LLSA QENI AGIP SAFL ELKK EEIK QRQI EQEK LASM KKQD EDKD KRDK EEKE |
| Gene ID: | 10250 |
| Uniprot: | Q8IYB3 |
| Cellular Location: | Nucleus matrix, Nucleus speckle |
| Calculated MW: | 102kDa |
| Observed MW: | 102kDa |
| Synonyms: | SRRM1, 160-KD, POP101, SRM160 |
| Background: |
| UniProt Protein Function: | SRm160: a Ser/Arg-related nuclear matrix protein. A splicing coactivator and component of the exon junction complex (EJC) involved in RNA export. Associates with proto-oncoprotein FUS on the nuclear matrix. Plays a role in spliceosome assembly. |
| UniProt Protein Details: | Protein type:RNA-binding; Spliceosome; RNA splicing Chromosomal Location of Human Ortholog: 1p36.11 Cellular Component: nucleoplasm; nuclear matrix; nuclear speck; nucleus; cytosol Molecular Function:DNA binding Biological Process: RNA splicing, via transesterification reactions; transcription from RNA polymerase II promoter; nuclear mRNA splicing, via spliceosome; mRNA export from nucleus; RNA splicing; gene expression; mRNA 3'-end processing; termination of RNA polymerase II transcription |
| UniProt Code: | Q8IYB3 |
| NCBI GenInfo Identifier: | 83305833 |
| NCBI Gene ID: | 10250 |
| NCBI Accession: | Q8IYB3.2 |
| UniProt Secondary Accession: | Q8IYB3,O60585, Q5VVN4, |
| UniProt Related Accession: | Q8IYB3 |
| Molecular Weight: | 904 |
| NCBI Full Name: | Serine/arginine repetitive matrix protein 1 |
| NCBI Synonym Full Names: | serine/arginine repetitive matrix 1 |
| NCBI Official Symbol: | SRRM1 |
| NCBI Official Synonym Symbols: | 160-KD; POP101; SRM160 |
| NCBI Protein Information: | serine/arginine repetitive matrix protein 1; Ser/Arg-related nuclear matrix protein; SR-related nuclear matrix protein of 160 kDa |
| UniProt Protein Name: | Serine/arginine repetitive matrix protein 1 |
| UniProt Synonym Protein Names: | SR-related nuclear matrix protein of 160 kDa; SRm160; Ser/Arg-related nuclear matrix protein |
| Protein Family: | Serine/arginine repetitive matrix protein |
| UniProt Gene Name: | SRRM1 |
| UniProt Entry Name: | SRRM1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SRRM1 antibody (CAB6066) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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