Cell Biology Antibodies 2
Anti-SRPRB Antibody (CAB10591)
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- SKU:
- CAB10591
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SRPRB Antibody |
| Antibody SKU: | CAB10591 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 57-271 of human SRPRB (NP_067026.3). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:1000 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, HT-29, LO2, , B cells, Mouse liver, Mouse pancreas, Mouse small intestine, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 57-271 of human SRPRB (NP_067026.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IRSR RSSQ RAVL LVGL CDSG KTLL FVRL LTGL YRDT QTSI TDSC AVYR VNNN RGNS LTLI DLPG HESL RLQF LERF KSSA RAIV FVVD SAAF QREV KDVA EFLY QVLI DSMG LKNT PSFL IACN KQDI AMAK SAKL IQQQ LEKE LNTL RVTR SAAP STLD SSST APAQ LGKK GKEF EFSQ LPLK VEFL ECSA KGGR GDVG SADI QDLE KWLA KIA |
| Gene ID: | 58477 |
| Uniprot: | Q9Y5M8 |
| Cellular Location: | Endoplasmic reticulum membrane, Single-pass membrane protein |
| Calculated MW: | 29kDa |
| Observed MW: | 30kDa |
| Synonyms: | SRPRB, APMCF1 |
| Background: | The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane. |
| UniProt Protein Function: | SRPRB: Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR. Belongs to the SRP receptor beta subunit family. |
| UniProt Protein Details: | Protein type:Endoplasmic reticulum; Membrane protein, integral; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 3q22.1 Cellular Component: cytoplasm; cytoplasmic microtubule; endoplasmic reticulum membrane; membrane; signal recognition particle receptor complex Molecular Function:signal recognition particle binding Biological Process: SRP-dependent cotranslational protein targeting to membrane |
| NCBI Summary: | The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y5M8 |
| NCBI GenInfo Identifier: | 31340540 |
| NCBI Gene ID: | 58477 |
| NCBI Accession: | Q9Y5M8.3 |
| UniProt Secondary Accession: | Q9Y5M8,Q6P595, Q8N2D8, |
| UniProt Related Accession: | Q9Y5M8 |
| Molecular Weight: | 30kDa |
| NCBI Full Name: | Signal recognition particle receptor subunit beta |
| NCBI Synonym Full Names: | SRP receptor beta subunit |
| NCBI Official Symbol: | SRPRB |
| NCBI Official Synonym Symbols: | APMCF1 |
| NCBI Protein Information: | signal recognition particle receptor subunit beta |
| UniProt Protein Name: | Signal recognition particle receptor subunit beta |
| UniProt Synonym Protein Names: | Protein APMCF1 |
| UniProt Gene Name: | SRPRB |
 | Western blot analysis of extracts of various cell lines, using SRPRB antibody (CAB10591) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunofluorescence analysis of H9C2 cells using SRPRB antibody (CAB10591) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of L929 cells using SRPRB antibody (CAB10591) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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