Name: Anti-SRPR Antibody (CAB5939)
Brand: Cell Biology Antibodies 9
SKU: CAB5939
Availability: OutOfStock

Antibody Name:	Anti-SRPR Antibody
Antibody SKU:	CAB5939
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human SRPR (NP_003130.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human
Positive Samples:	A-549, HT-1080

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human SRPR (NP_003130.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MLDF FTIF SKGG LVLW CFQG VSDS CTGP VNAL IRSV LLQE RGGN NSFT HEAL TLKY KLDN QFEL VFVV GFQK ILTL TYVD KLID DVHR LFRD KYRT EIQQ QSAL SLLN GTFD FQND FLRL LREA EESS KIRA PTTM KKFE DSEK AKKP VRSM IETR GEKP KEKA KNSK KKGA KKEG SDGP LATS KPVP AEKS GLPV GPEN GVEL SKEE LIRR KREE FIQK
Gene ID:	6734
Uniprot:	P08240
Cellular Location:	Endoplasmic reticulum membrane, Peripheral membrane protein
Calculated MW:	66kDa/69kDa
Observed MW:	75kDa

Synonyms:	SRPRA, DP, SRPR, Sralpha
Background:	The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged secretory and membrane proteins across the endoplasmic reticulum. Alternative splicing results in multiple transcript variants.

UniProt Protein Function:	SRPR: Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Belongs to the GTP-binding SRP family.
UniProt Protein Details:	Protein type:Endoplasmic reticulum Chromosomal Location of Human Ortholog: 11q24.2 Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; signal recognition particle receptor complex; integral to membrane Molecular Function:GTPase activity; GTP binding; signal recognition particle binding Biological Process: SRP-dependent cotranslational protein targeting to membrane; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; translation; unfolded protein response; gene expression; cotranslational protein targeting to membrane
NCBI Summary:	The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged secretory and membrane proteins across the endoplasmic reticulum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
UniProt Code:	P08240
NCBI GenInfo Identifier:	20455516
NCBI Gene ID:	6734
NCBI Accession:	P08240.2
UniProt Secondary Accession:	P08240,Q9BVJ4, A6NIB3, B2R5Z8, B4E0H3, E9PJS4,
UniProt Related Accession:	P08240
Molecular Weight:	638
NCBI Full Name:	Signal recognition particle receptor subunit alpha
NCBI Synonym Full Names:	signal recognition particle receptor (docking protein)
NCBI Official Symbol:	SRPR
NCBI Official Synonym Symbols:	DP; Sralpha
NCBI Protein Information:	signal recognition particle receptor subunit alpha; DP-alpha; SR-alpha; SRP-alpha; docking protein alpha
UniProt Protein Name:	Signal recognition particle receptor subunit alpha
UniProt Synonym Protein Names:	Docking protein alpha; DP-alpha
Protein Family:	HTH-type transcriptional regulator
UniProt Gene Name:	SRPR
UniProt Entry Name:	SRPR_HUMAN

Western blot analysis of extracts of various cell lines, using SRPR antibody (CAB5939) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.

Antibodies

SRPR Antibody (PACO12466)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)