Cell Biology Antibodies 9
Anti-SRP54 Antibody (CAB4126)
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- SKU:
- CAB4126
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SRP54 Antibody |
| Antibody SKU: | CAB4126 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 196-455 of human SRP54 (NP_001139754.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, Mouse brain, Mouse heart, Mouse liver, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 196-455 of human SRP54 (NP_001139754.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VIVT KLDG HAKG GGAL SAVA ATKS PIIF IGTG EHID DFEP FKTQ PFIS KLLG MGDI EGLI DKVN ELKL DDNE ALIE KLKH GQFT LRDM YEQF QNIM KMGP FSQI LGMI PGFG TDFM SKGN EQES MARL KKLM TIMD SMND QELD STDG AKVF SKQP GRIQ RVAR GSGV STRD VQEL LTQY TKFA QMVK KMGG IKGL FKGG DMSK NVSQ SQMA KLNQ QMAK MMDP RVLH HMGG MAGL QSMM RQFQ QGAA GNMK GMMG FNNM |
| Gene ID: | 6729 |
| Uniprot: | P61011 |
| Cellular Location: | Cytoplasm, Nucleus speckle |
| Calculated MW: | 50kDa/55kDa |
| Observed MW: | 56kDa |
| Synonyms: | SRP54 |
| Background: |
| UniProt Protein Function: | SRP54: Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA-binding Chromosomal Location of Human Ortholog: 14q13.2 Cellular Component: cytoplasm; signal recognition particle, endoplasmic reticulum targeting; nucleolus; nuclear speck; nucleus; cytosol Molecular Function:GTPase activity; ribonucleoprotein binding; GDP binding; GTP binding; drug binding; endoplasmic reticulum signal peptide binding; 7S RNA binding Biological Process: response to drug; SRP-dependent cotranslational protein targeting to membrane, translocation; SRP-dependent cotranslational protein targeting to membrane; protein targeting to ER; cellular protein metabolic process; translation; SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition; gene expression |
| UniProt Code: | P61011 |
| NCBI GenInfo Identifier: | 46577650 |
| NCBI Gene ID: | 6729 |
| NCBI Accession: | P61011.1 |
| UniProt Secondary Accession: | P61011,P14576, |
| UniProt Related Accession: | P61011 |
| Molecular Weight: | 504 |
| NCBI Full Name: | Signal recognition particle 54 kDa protein |
| NCBI Synonym Full Names: | signal recognition particle 54kDa |
| NCBI Official Symbol: | SRP54 |
| NCBI Protein Information: | signal recognition particle 54 kDa protein; signal recognition particle 54kD |
| UniProt Protein Name: | Signal recognition particle 54 kDa protein |
| Protein Family: | Signal recognition particle |
| UniProt Gene Name: | SRP54 |
| UniProt Entry Name: | SRP54_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SRP54 antibody (CAB4126) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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