Cell Biology Antibodies 3
Anti-SRP14 Antibody (CAB12926)
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- SKU:
- CAB12926
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SRP14 Antibody |
| Antibody SKU: | CAB12926 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-136 of human SRP14 (NP_003125.3). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, 22Rv1, HT-29, HepG2, A-549 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-136 of human SRP14 (NP_003125.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MVLL ESEQ FLTE LTRL FQKC RTSG SVYI TLKK YDGR TKPI PKKG TVEG FEPA DNKC LLRA TDGK KKIS TVVS SKEV NKFQ MAYS NLLR ANMD GLKK RDKK NKTK KTKA AAAA AAAA PAAA ATAP TTAA TTAA TAAQ |
| Gene ID: | 6727 |
| Uniprot: | P37108 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 14kDa |
| Observed MW: | 15-18kDa |
| Synonyms: | SRP14, ALURBP |
| Background: |
| UniProt Protein Function: | SRP14: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding. Belongs to the SRP14 family. |
| UniProt Protein Details: | Protein type:RNA-binding; Translation Chromosomal Location of Human Ortholog: 15q22 Cellular Component: intercellular bridge; cytoplasm; nucleolus; signal recognition particle, endoplasmic reticulum targeting; cytosol; nucleus Molecular Function:protein binding; RNA binding; endoplasmic reticulum signal peptide binding; 7S RNA binding Biological Process: response to drug; SRP-dependent cotranslational protein targeting to membrane; protein targeting to ER; cellular protein metabolic process; translation; gene expression; cotranslational protein targeting to membrane |
| UniProt Code: | P37108 |
| NCBI GenInfo Identifier: | 116242801 |
| NCBI Gene ID: | 6727 |
| NCBI Accession: | P37108.2 |
| UniProt Secondary Accession: | P37108,Q6B0K5, Q96Q14, B5BUF5, |
| UniProt Related Accession: | P37108 |
| Molecular Weight: | 136 |
| NCBI Full Name: | Signal recognition particle 14 kDa protein |
| NCBI Synonym Full Names: | signal recognition particle 14kDa (homologous Alu RNA binding protein) |
| NCBI Official Symbol: | SRP14 |
| NCBI Official Synonym Symbols: | ALURBP |
| NCBI Protein Information: | signal recognition particle 14 kDa protein; 18 kDa Alu RNA-binding protein |
| UniProt Protein Name: | Signal recognition particle 14 kDa protein |
| UniProt Synonym Protein Names: | 18 kDa Alu RNA-binding protein |
| Protein Family: | Signal recognition particle |
| UniProt Gene Name: | SRP14 |
| UniProt Entry Name: | SRP14_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SRP14 antibody (CAB12926) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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