Anti-SRGAP2 Antibody (CAB19512)

(No reviews yet) Write a Review
SKU:
CAB19512
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
SRGAP2
Synonyms:
ARHGAP34
Synonyms:
FNBP2
Synonyms:
SRGAP2A
Synonyms:
SRGAP3

Description

Product Name:SRGAP2 Rabbit pAb
Product Code:CAB19512
Size:50uL, 100uL
Synonyms:SRGAP2, ARHGAP34, FNBP2, SRGAP2A, SRGAP3
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic Peptide of human SRGAP2
Applications:WB
Recommended Dilutions:WB 1:500 - 1:1000
Reactivity:Human, Mouse
Positive Samples:Mouse brain
Immunogen:A synthetic Peptide of human SRGAP2
Purification Method:Affinity purification
Storage:Store at 4°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:23380
Uniprot:O75044
Cellular Location:Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Nucleus, dendritic spine, lamellipodium, phagosome, postsynaptic cell membrane, postsynaptic density, synapse
Calculated MW:120kDa
Observed MW:140KDa
UniProt Protein Function:SRGAP2: RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia. A chromosomal aberration disrupting SRGAP2 has been found in a patient with early infantile epileptic encephalopathy. Balanced translocation t(1;9)(q32;q13).
UniProt Protein Details:

Protein type:GAPs; Motility/polarity/chemotaxis; Mitochondrial; GAPs, Rac/Rho

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: cytoplasm; cytosol; lamellipodium; phagocytic vesicle; plasma membrane; postsynaptic density; postsynaptic membrane

Molecular Function:GTPase activator activity; protein binding; protein homodimerization activity; Rac GTPase binding

Biological Process: actin filament severing; cell proliferation; extension of a leading process involved in cell locomotion in cerebral cortex radial glia guided migration; filopodium formation; neurite morphogenesis; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction

NCBI Summary:This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014]
UniProt Code:O75044
NCBI GenInfo Identifier:48427907
NCBI Gene ID:23380
NCBI Accession:O75044.2
UniProt Related Accession:O75044
Molecular Weight:120,881 Da
NCBI Full Name:SLIT-ROBO Rho GTPase-activating protein 2
NCBI Synonym Full Names:SLIT-ROBO Rho GTPase activating protein 2
NCBI Official Symbol:SRGAP2  
NCBI Official Synonym Symbols:FNBP2; SRGAP3; SRGAP2A; ARHGAP34  
NCBI Protein Information:SLIT-ROBO Rho GTPase-activating protein 2
UniProt Protein Name:SLIT-ROBO Rho GTPase-activating protein 2
UniProt Synonym Protein Names:Formin-binding protein 2; Rho GTPase-activating protein 34
Protein Family:SLIT-ROBO Rho GTPase-activating protein
UniProt Gene Name:SRGAP2  
UniProt Entry Name:SRGP2_HUMAN
View AllClose

0 Reviews

View AllClose

Related Products