Neuroscience
Anti-SRGAP1 Antibody (CAB16194)
- SKU:
- CAB16194
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Neuroscience
Description
| Antibody Name: | Anti-SRGAP1 Antibody |
| Antibody SKU: | CAB16194 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human SRGAP1 (NP_065813.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human SRGAP1 (NP_065813.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSTP SRFK KDKE IIAE YESQ VKEI RAQL VEQQ KCLE QQTE MRVQ LLQD LQDF FRKK AEIE TEYS RNLE KLAE RFMA KTRS TKDH QQYK KDQN LLSP VNCW YLLL NQVR RESK DHAT LSDI YLNN VIMR FMQI SEDS TRMF KKSK EIAF QLHE DLMK VLNE |
| Gene ID: | 57522 |
| Uniprot: | Q7Z6B7 |
| Cellular Location: | |
| Calculated MW: | 121kDa/124kDa |
| Observed MW: | Refer to figures |
| Synonyms: | SRGAP1, ARHGAP13, NMTC2 |
| Background: | The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42. |
| UniProt Protein Function: | ARHGAP13: GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GAPs; GAPs, Rac/Rho Chromosomal Location of Human Ortholog: 12q14.2 Cellular Component: cytoplasm; cytosol Molecular Function:GTPase activator activity; protein binding; Rac GTPase binding Biological Process: negative regulation of cell migration; regulation of small GTPase mediated signal transduction Disease: Thyroid Carcinoma, Follicular |
| UniProt Code: | Q7Z6B7 |
| NCBI GenInfo Identifier: | 48428624 |
| NCBI Gene ID: | 57522 |
| NCBI Accession: | Q7Z6B7.1 |
| UniProt Secondary Accession: | Q7Z6B7,Q9H8A3, Q9P2P2, |
| UniProt Related Accession: | Q7Z6B7 |
| Molecular Weight: | 121,594 Da |
| NCBI Full Name: | SLIT-ROBO Rho GTPase-activating protein 1 |
| NCBI Synonym Full Names: | SLIT-ROBO Rho GTPase activating protein 1 |
| NCBI Official Symbol: | SRGAP1 |
| NCBI Official Synonym Symbols: | NMTC2; ARHGAP13 |
| NCBI Protein Information: | SLIT-ROBO Rho GTPase-activating protein 1 |
| UniProt Protein Name: | SLIT-ROBO Rho GTPase-activating protein 1 |
| UniProt Synonym Protein Names: | Rho GTPase-activating protein 13 |
| Protein Family: | SLIT-ROBO Rho GTPase-activating protein |
| UniProt Gene Name: | SRGAP1 |
| UniProt Entry Name: | SRGP1_HUMAN |
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