Epigenetics & Nuclear Signaling Antibodies 1
Anti-SREK1 Antibody (CAB13235)
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- SKU:
- CAB13235
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-SREK1 Antibody |
| Antibody SKU: | CAB13235 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human SREK1 (NP_631907.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | MCF7, HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human SREK1 (NP_631907.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTSL MPGA GLLP IPTP NPLT TLGV SLSS LGAI PAAA LDPN IATL GEIP QPPL MGNV DPSK IDEI RRTV YVGN LNSQ TTTA DQLL EFFK QVGE VKFV RMAG DETQ PTRF AFVE FADQ NSVP RALA FNGV MFGD RPLK INHS NNAI VKPP EMTP QAAA KELE EVMK RVRE AQSF ISAA IEPE |
| Gene ID: | 140890 |
| Uniprot: | Q8WXA9 |
| Cellular Location: | Nucleus |
| Calculated MW: | 59kDa/71kDa |
| Observed MW: | 59kDa |
| Synonyms: | SREK1, SFRS12, SRrp508, SRrp86 |
| Background: | This gene encodes a member of a family of serine/arginine-rich (SR) splicing proteins containing RNA recognition motif (RRM) domains. The encoded protein interacts with other SR proteins to modulate splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3. |
| NCBI Summary: | This gene encodes a member of a family of serine/arginine-rich (SR) splicing proteins containing RNA recognition motif (RRM) domains. The encoded protein interacts with other SR proteins to modulate splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] |
| UniProt Code: | Q8WXA9 |
| NCBI GenInfo Identifier: | 116089325 |
| NCBI Gene ID: | 140890 |
| NCBI Accession: | NP_001070667.1 |
| UniProt Secondary Accession: | Q8WXA9,Q2M1J0, Q86X37, A4FTW3, |
| UniProt Related Accession: | Q8WXA9 |
| Molecular Weight: | 17.3 kDa |
| NCBI Full Name: | splicing regulatory glutamine/lysine-rich protein 1 isoform a |
| NCBI Synonym Full Names: | splicing regulatory glutamic acid and lysine rich protein 1 |
| NCBI Official Symbol: | SREK1 |
| NCBI Official Synonym Symbols: | SFRS12; SRrp86; SRrp508 |
| NCBI Protein Information: | splicing regulatory glutamine/lysine-rich protein 1 |
| UniProt Protein Name: | Splicing regulatory glutamine/lysine-rich protein 1 |
| UniProt Synonym Protein Names: | Serine/arginine-rich-splicing regulatory protein 86; SRrp86; Splicing factor, arginine/serine-rich 12; Splicing regulatory protein 508; SRrp508 |
| Protein Family: | Splicing regulatory glutamine/lysine-rich protein |
| UniProt Gene Name: | SREK1 |
 | Western blot analysis of extracts of various cell lines, using SREK1 antibody (CAB13235) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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