Metabolism Antibodies 1
Anti-SREBP2 Antibody (CAB13049)
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- SKU:
- CAB13049
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-SREBP2 Antibody |
| Antibody SKU: | CAB13049 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human SREBF2 (NP_004590.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:1000 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, LO2, 293T, HeLa, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human SREBF2 (NP_004590.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDDS GELG GLET METL TELG DELT LGDI DEML QFVS NQVG EFPD LFSE QLCS SFPG SGGS GSSS GSSG SSSS SSNG RGSS SGAV DPSV QRSF TQVT LPSF SPSA ASPQ APTL QVKV SPTS VPTT PRAT PILQ PRPQ PQPQ PQTQ LQQQ TVMI TPTF STTP QTRI IQQP LIYQ NAAT SFQV LQPQ VQSL VTSS QVQP VTIQ QQVQ TVQA QRVL TQTA NGTL |
| Gene ID: | 6721 |
| Uniprot: | Q12772 |
| Cellular Location: | COPII-coated vesicle membrane, Cytoplasmic vesicle, Endoplasmic reticulum membrane, Golgi apparatus membrane, Multi-pass membrane protein, Multi-pass membrane protein, Nucleus |
| Calculated MW: | 73kDa/123kDa |
| Observed MW: | 60kDa |
| Synonyms: | SREBF2, SREBP-2, SREBP2, bHLHd2 |
| Background: | This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | Transcriptional activator required for lipid homeostasis. May regulate transcription of the LDL receptor gene as well as the cholesterol and fatty acid synthesis pathways. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes. |
| UniProt Code: | Q12772 |
| NCBI GenInfo Identifier: | 148235634 |
| NCBI Gene ID: | 100037309 |
| NCBI Accession: | NP_001082935.1 |
| UniProt Related Accession: | A3KNA7 |
| Molecular Weight: | 120321 |
| NCBI Full Name: | sterol regulatory element-binding protein 2 |
| NCBI Synonym Full Names: | sterol regulatory element binding transcription factor 2 |
| NCBI Official Symbol: | srebf2 |
| NCBI Official Synonym Symbols: | zgc:158371 |
| NCBI Protein Information: | sterol regulatory element-binding protein 2 |
| UniProt Protein Name: | Sterol regulatory element-binding protein 2 |
| UniProt Synonym Protein Names: | Sterol regulatory element-binding transcription factor 2 |
| Protein Family: | Sterol regulatory element-binding protein |
| UniProt Gene Name: | srebf2 |
| UniProt Entry Name: | SRBP2_DANRE |
 | Western blot analysis of extracts of various cell lines, using SREBP2 antibody (CAB13049) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunohistochemistry of paraffin-embedded Human gastric cancer using SREBP2 antibody (CAB13049) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of L929 cells using SREBP2 Rabbit pAb (CAB13049) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of U2OS cells using SREBP2 Rabbit pAb (CAB13049) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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