Cell Biology Antibodies 15

Anti-SRCAP Antibody (CAB17933)

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SKU:
CAB17933
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-SRCAP Antibody
Antibody SKU:CAB17933
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human SRCAP.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant protein of human SRCAP.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10847
Uniprot:Q6ZRS2
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:DOMO1, EAF1, FLHS, SWR1, SRCAP
Background:
UniProt Protein Function:SRCAP: Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. Defects in SRCAP are the cause of Floating-Harbor syndrome (FLHS). A rare genetic disorder characterized by proportionate short stature, delayed bone age, delayed speech development, and typical facial features. The face is triangular with deep-set eyes, long eyelashes, bulbous nose, wide columella, short philtrum, and thin lips. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding; Acetyltransferase; EC 3.6.4.-; Helicase; EC 3.6.1.-; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: nucleoplasm; Golgi apparatus; protein complex; perinuclear region of cytoplasm; nucleus

Molecular Function:protein binding; histone acetyltransferase activity; DNA binding; transcription coactivator activity; helicase activity; ATP binding

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; viral reproduction; histone acetylation

Disease: Floating-harbor Syndrome

NCBI Summary:This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]
UniProt Code:Q6ZRS2
NCBI GenInfo Identifier:146219843
NCBI Gene ID:10847
NCBI Accession:NP_006653.2
UniProt Secondary Accession:Q6ZRS2,O15026, Q7Z744, Q9Y5L9, B0JZA6,
UniProt Related Accession:Q6ZRS2
Molecular Weight:327,838 Da
NCBI Full Name:helicase SRCAP
NCBI Synonym Full Names:Snf2-related CREBBP activator protein
NCBI Official Symbol:SRCAP  
NCBI Official Synonym Symbols:EAF1; FLHS; SWR1; DOMO1  
NCBI Protein Information:helicase SRCAP; domino homolog 2; Snf2-related CBP activator protein; Swi2/Snf2-related ATPase homolog, domino homolog 1
UniProt Protein Name:Helicase SRCAP
UniProt Synonym Protein Names:Domino homolog 2; Snf2-related CBP activator
Protein Family:Helicase
UniProt Gene Name:SRCAP  
UniProt Entry Name:SRCAP_HUMAN
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