Cell Biology Antibodies 9

Anti-SPTBN1 Antibody (CAB5253)

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SKU:
CAB5253
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-SPTBN1 Antibody
Antibody SKU:CAB5253
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 2100-2200 of human SPTBN1 (NP_003119.2).
Application:WB
Recommended Dilution:WB 1:1000 - 1:3000
Reactivity:Human, Mouse
Positive Samples:U-87MG, HeLa, Jurkat, LO2, 293T, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 2100-2200 of human SPTBN1 (NP_003119.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PPSP EPST KVSE EAES QQQW DTSK GEQV SQNG LPAE QGSP RMAE TVDT SEMV NGAT EQRT SSKE SSPI PSPT SDRK AKTA LPAQ SAAT LPAR TQET PSAQ M
Gene ID:6711
Uniprot:Q01082
Cellular Location:Cell membrane, Cytoplasm, Cytoplasmic side, M line, Peripheral membrane protein, cytoskeleton, myofibril, sarcomere
Calculated MW:251kDa/253kDa/274kDa
Observed MW:275kDa
Synonyms:SPTBN1, ELF, HEL102, SPTB2, betaSpII, spectrin beta
Background:Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
NCBI Summary:Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q01082
NCBI GenInfo Identifier:116242799
NCBI Gene ID:6711
NCBI Accession:Q01082.2
UniProt Secondary Accession:Q01082,O60837, Q16057, Q53R99, Q59ER3, Q8IX99, B2RP63
UniProt Related Accession:Q01082
Molecular Weight:251,397 Da
NCBI Full Name:Spectrin beta chain, non-erythrocytic 1
NCBI Synonym Full Names:spectrin beta, non-erythrocytic 1
NCBI Official Symbol:SPTBN1  
NCBI Official Synonym Symbols:ELF; SPTB2; HEL102; betaSpII  
NCBI Protein Information:spectrin beta chain, non-erythrocytic 1
UniProt Protein Name:Spectrin beta chain, non-erythrocytic 1
UniProt Synonym Protein Names:Beta-II spectrin; Fodrin beta chain; Spectrin, non-erythroid beta chain 1
Protein Family:Spectrin
UniProt Gene Name:SPTBN1  
UniProt Entry Name:SPTB2_HUMAN
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