Cell Biology Antibodies 12

Anti-SPO11 Antibody (CAB9109)

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SKU:
CAB9109
Product Type:
Antibody
Applications:
WB
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-SPO11 Antibody
Antibody SKU:CAB9109
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 269-358 of human SPO11 (NP_937998.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 269-358 of human SPO11 (NP_937998.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AIRW LGLL PSDL KRLN VPKD SLIP LTKR DQMK LDSI LRRP YVTC QPFW RKEM EIMA DSKM KAEI QALT FLSS DYLS RVYL PNKL KFGG WI
Gene ID:23626
Uniprot:Q9Y5K1
Cellular Location:Nucleus
Calculated MW:40kDa/44kDa
Observed MW:Refer to figures
Synonyms:SPO11, CT35, SPATA43, TOPVIA
Background:Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described.
UniProt Protein Function:SPO11: Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. Belongs to the TOP6A family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell cycle regulation; Cancer Testis Antigen (CTA); Cell development/differentiation

Chromosomal Location of Human Ortholog: 20q13.31

Molecular Function:protein binding

Biological Process: female gamete generation; spermatogenesis

NCBI Summary:Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y5K1
NCBI GenInfo Identifier:7674367
NCBI Gene ID:23626
NCBI Accession:Q9Y5K1.1
UniProt Secondary Accession:Q9Y5K1,Q5TCI1, Q8N4V0, Q9NQM7, Q9NQM8,
UniProt Related Accession:Q9Y5K1
Molecular Weight:40,364 Da
NCBI Full Name:Meiotic recombination protein SPO11
NCBI Synonym Full Names:SPO11, initiator of meiotic double stranded breaks
NCBI Official Symbol:SPO11  
NCBI Official Synonym Symbols:CT35; TOPVIA; SPATA43  
NCBI Protein Information:meiotic recombination protein SPO11
UniProt Protein Name:Meiotic recombination protein SPO11
UniProt Synonym Protein Names:Cancer/testis antigen 35; CT35
Protein Family:Meiosis-specific protein
UniProt Gene Name:SPO11  
UniProt Entry Name:SPO11_HUMAN
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