Cell Biology Antibodies 9

Anti-SPK Antibody (CAB4852)

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SKU:
CAB4852
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
PBK
Synonyms:
CT84
Synonyms:
HEL164
Synonyms:
Nori-3
Synonyms:
SPK
Synonyms:
TOPK
Research Area:
Cell Biology

Description

Product Name:SPK Rabbit pAb
Product Code:CAB4852
Size:20uL, 50uL, 100uL
Synonyms:PBK, CT84, HEL164, Nori-3, SPK, TOPK
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-322 of human SPK (NP_060962.2).
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:SW480, THP-1, NCI-H460
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-322 of human SPK (NP_060962.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEGI SNFK TPSK LSEK KKSV LCST PTIN IPAS PFMQ KLGF GTGV NVYL MKRS PRGL SHSP WAVK KINP ICND HYRS VYQK RLMD EAKI LKSL HHPN IVGY RAFT EAND GSLC LAME YGGE KSLN DLIE ERYK ASQD PFPA AIIL KVAL NMAR GLKY LHQE KKLL HGDI KSSN VVIK GDFE TIKI CDVG VSLP LDEN MTVT DPEA CYIG TEPW KPKE AVEE NGVI TDKA DIFA FGLT LWEM MTLS IPHI NLSN DDDD EDKT FDES DFDD EAYY AALG TRPP INME ELDE SYQK VIEL FSVC TNED PKDR PSAA HIVE ALET DV
Gene ID:55872
Uniprot:Q96KB5
Calculated MW:36kDa/37kDa
Observed MW:36kDa
UniProt Protein Function:PBK: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. Interacts with DLG1 and TP53. Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules. Activated by phosphorylation. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase kinase subfamily.
UniProt Protein Details:

Protein type:EC 2.7.12.2; Cancer Testis Antigen (CTA); Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, Other; Other group; TOPK family

Chromosomal Location of Human Ortholog: 8p21.2

Cellular Component: nucleus

Molecular Function:ATP binding; protein binding; protein serine/threonine kinase activity

Biological Process: mitosis; negative regulation of inflammatory response; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of stress-activated MAPK cascade; protein amino acid phosphorylation

NCBI Summary:This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Code:Q96KB5
NCBI GenInfo Identifier:83305809
NCBI Gene ID:55872
NCBI Accession:Q96KB5.3
UniProt Secondary Accession:Q96KB5,Q9NPD9, Q9NYL7, Q9NZK6, B4DX68, D3DST2,
UniProt Related Accession:Q96KB5
Molecular Weight:37,211 Da
NCBI Full Name:Lymphokine-activated killer T-cell-originated protein kinase
NCBI Synonym Full Names:PDZ binding kinase
NCBI Official Symbol:PBK  
NCBI Official Synonym Symbols:SPK; CT84; TOPK; HEL164; Nori-3  
NCBI Protein Information:lymphokine-activated killer T-cell-originated protein kinase
UniProt Protein Name:Lymphokine-activated killer T-cell-originated protein kinase
UniProt Synonym Protein Names:Cancer/testis antigen 84; CT84; MAPKK-like protein kinase; Nori-3; PDZ-binding kinase; Spermatogenesis-related protein kinase; SPK; T-LAK cell-originated protein kinase
Protein Family:Lymphokine-activated killer T-cell-originated protein kinase
UniProt Gene Name:PBK  
UniProt Entry Name:TOPK_HUMAN
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