Cell Biology Antibodies 9
Anti-SPK Antibody (CAB4852)
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- SKU:
- CAB4852
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PBK
- Synonyms:
- CT84
- Synonyms:
- HEL164
- Synonyms:
- Nori-3
- Synonyms:
- SPK
- Synonyms:
- TOPK
- Research Area:
- Cell Biology
Description
| Product Name: | SPK Rabbit pAb |
| Product Code: | CAB4852 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | PBK, CT84, HEL164, Nori-3, SPK, TOPK |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-322 of human SPK (NP_060962.2). |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW480, THP-1, NCI-H460 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-322 of human SPK (NP_060962.2). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEGI SNFK TPSK LSEK KKSV LCST PTIN IPAS PFMQ KLGF GTGV NVYL MKRS PRGL SHSP WAVK KINP ICND HYRS VYQK RLMD EAKI LKSL HHPN IVGY RAFT EAND GSLC LAME YGGE KSLN DLIE ERYK ASQD PFPA AIIL KVAL NMAR GLKY LHQE KKLL HGDI KSSN VVIK GDFE TIKI CDVG VSLP LDEN MTVT DPEA CYIG TEPW KPKE AVEE NGVI TDKA DIFA FGLT LWEM MTLS IPHI NLSN DDDD EDKT FDES DFDD EAYY AALG TRPP INME ELDE SYQK VIEL FSVC TNED PKDR PSAA HIVE ALET DV |
| Gene ID: | 55872 |
| Uniprot: | Q96KB5 |
| Calculated MW: | 36kDa/37kDa |
| Observed MW: | 36kDa |
| UniProt Protein Function: | PBK: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. Interacts with DLG1 and TP53. Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules. Activated by phosphorylation. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase kinase subfamily. |
| UniProt Protein Details: | Protein type:EC 2.7.12.2; Cancer Testis Antigen (CTA); Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, Other; Other group; TOPK family Chromosomal Location of Human Ortholog: 8p21.2 Cellular Component: nucleus Molecular Function:ATP binding; protein binding; protein serine/threonine kinase activity Biological Process: mitosis; negative regulation of inflammatory response; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of stress-activated MAPK cascade; protein amino acid phosphorylation |
| NCBI Summary: | This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q96KB5 |
| NCBI GenInfo Identifier: | 83305809 |
| NCBI Gene ID: | 55872 |
| NCBI Accession: | Q96KB5.3 |
| UniProt Secondary Accession: | Q96KB5,Q9NPD9, Q9NYL7, Q9NZK6, B4DX68, D3DST2, |
| UniProt Related Accession: | Q96KB5 |
| Molecular Weight: | 37,211 Da |
| NCBI Full Name: | Lymphokine-activated killer T-cell-originated protein kinase |
| NCBI Synonym Full Names: | PDZ binding kinase |
| NCBI Official Symbol: | PBK |
| NCBI Official Synonym Symbols: | SPK; CT84; TOPK; HEL164; Nori-3 |
| NCBI Protein Information: | lymphokine-activated killer T-cell-originated protein kinase |
| UniProt Protein Name: | Lymphokine-activated killer T-cell-originated protein kinase |
| UniProt Synonym Protein Names: | Cancer/testis antigen 84; CT84; MAPKK-like protein kinase; Nori-3; PDZ-binding kinase; Spermatogenesis-related protein kinase; SPK; T-LAK cell-originated protein kinase |
| Protein Family: | Lymphokine-activated killer T-cell-originated protein kinase |
| UniProt Gene Name: | PBK |
| UniProt Entry Name: | TOPK_HUMAN |
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