Cell Biology Antibodies 2
Anti-SPINK1 Antibody (CAB1096)
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- SKU:
- CAB1096
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SPINK1 Antibody |
| Antibody SKU: | CAB1096 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-79 of human SPINK1 (NP_003113.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse intestine |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-79 of human SPINK1 (NP_003113.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DSLG REAK CYNE LNGC TKIY DPVC GTDG NTYP NECV LCFE NRKR QTSI LIQK SGPC |
| Gene ID: | 6690 |
| Uniprot: | P00995 |
| Cellular Location: | Secreted |
| Calculated MW: | 8kDa |
| Observed MW: | 12kDa |
| Synonyms: | SPINK1, PCTT, PSTI, Spink3, TATI, TCP |
| Background: | The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. |
| UniProt Protein Function: | SPINK1: This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. Defects in SPINK1 are a cause of pancreatitis (PCTT). A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. Defects in SPINK1 are the cause of susceptibility to tropical calcific pancreatitis (TCP). TCP is an idiopathic, juvenile, nonalcoholic form of chronic pancreatitis widely prevalent in several tropical countries. It can be associated with fibrocalculous pancreatic diabetes (FCPD) depending on both environmental and genetic factors. TCP differs from alcoholic pancreatitis by a much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant diabetes mellitus, and an exceptionally high incidence of pancreatic cancer. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 5q32 Cellular Component: extracellular space Molecular Function:serine-type endopeptidase inhibitor activity; protein binding; endopeptidase inhibitor activity Biological Process: negative regulation of peptidyl-tyrosine phosphorylation; regulation of acrosome reaction Disease: Tropical Calcific Pancreatitis; Pancreatitis, Hereditary |
| NCBI Summary: | The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. [provided by RefSeq, Oct 2008] |
| UniProt Code: | P00995 |
| NCBI GenInfo Identifier: | 124856 |
| NCBI Gene ID: | 6690 |
| NCBI Accession: | P00995.2 |
| UniProt Related Accession: | P00995 |
| Molecular Weight: | 79 |
| NCBI Full Name: | Pancreatic secretory trypsin inhibitor |
| NCBI Synonym Full Names: | serine peptidase inhibitor, Kazal type 1 |
| NCBI Official Symbol: | SPINK1 |
| NCBI Official Synonym Symbols: | TCP; PCTT; PSTI; TATI; Spink3 |
| NCBI Protein Information: | pancreatic secretory trypsin inhibitor; tumor-associated trypsin inhibitor; serine protease inhibitor, Kazal type 1 |
| UniProt Protein Name: | Pancreatic secretory trypsin inhibitor |
| UniProt Synonym Protein Names: | Serine protease inhibitor Kazal-type 1; Tumor-associated trypsin inhibitor; TATI |
| Protein Family: | Serine protease inhibitor |
| UniProt Gene Name: | SPINK1 |
| UniProt Entry Name: | ISK1_HUMAN |
 | Western blot analysis of extracts of mouse intestine, using SPINK1 antibody (CAB1096) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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