Cell Biology Antibodies 1
Anti-SPG11 Antibody (CAB10326)
(No reviews yet)
Write a Review
- SKU:
- CAB10326
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SPG11 Antibody |
| Antibody SKU: | CAB10326 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 550-750 of human SPG11 (NP_079413.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-87MG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 550-750 of human SPG11 (NP_079413.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KSKE NLFN PSSK SSVS DQFD HLSS HLYL RNVE ELIP ALDL LCSA IRES YSEP QSKH FSEQ LLNL TLSF LNNQ IKEL FIHT EELD EHLQ KGVN ILTS YINE LRTF MIKF PWKL TDAI DEYD VHEN VPKV KESN IWKK LSFE EVIA SAIL NNKI PEAQ TFFR IDSH SAQK LEEL IGIG LNLV FDNL KKNN IKEA SELL KNMG F |
| Gene ID: | 80208 |
| Uniprot: | Q96JI7 |
| Cellular Location: | Cytoplasm, Membrane, Multi-pass membrane protein, Nucleus, cytosol |
| Calculated MW: | 236kDa/266kDa/278kDa |
| Observed MW: | 280kDa |
| Synonyms: | SPG11, ALS5, CMT2X, KIAA1840, spatacsin |
| Background: | The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | SPG11: Defects in SPG11 are the cause of spastic paraplegia autosomal recessive type 11 (SPG11). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 15q21.1 Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; lysosomal membrane; nucleolus; plasma membrane; synapse Molecular Function:protein binding Biological Process: axon cargo transport; synaptic transmission; synaptic vesicle transport Disease: Amyotrophic Lateral Sclerosis 5, Juvenile; Charcot-marie-tooth Disease, Axonal, Type 2x; Spastic Paraplegia 11, Autosomal Recessive |
| NCBI Summary: | The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] |
| UniProt Code: | Q96JI7 |
| NCBI GenInfo Identifier: | 296452946 |
| NCBI Gene ID: | 80208 |
| NCBI Accession: | Q96JI7.3 |
| UniProt Secondary Accession: | Q96JI7,Q4VC11, Q58G86, Q69YG6, Q6NW01, Q8N270, Q8TBU9 Q9H734, A8KAX9, B9EK60, F5H3N6, |
| UniProt Related Accession: | Q96JI7 |
| Molecular Weight: | 279kDa |
| NCBI Full Name: | Spatacsin |
| NCBI Synonym Full Names: | SPG11, spatacsin vesicle trafficking associated |
| NCBI Official Symbol: | SPG11 |
| NCBI Official Synonym Symbols: | ALS5; CMT2X; KIAA1840 |
| NCBI Protein Information: | spatacsin |
| UniProt Protein Name: | Spatacsin |
| UniProt Synonym Protein Names: | Colorectal carcinoma-associated protein; Spastic paraplegia 11 protein |
| Protein Family: | Spatacsin |
| UniProt Gene Name: | SPG11 |
 | Western blot analysis of extracts of U-87MG cells, using SPG11 antibody (CAB10326) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
Related Products
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
Human Anti-DSG3 antibody(anti-Desmoglein-3 antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
Human anti-ASGPR antibody(anti asialoglyco protein receptor antibody)ELISA Kit
OverviewProduct Name:Human anti-ASGPR antibody(anti asialoglyco protein receptor antibody)ELISA KitProduct Code:AEFI00360Size:96TAlias:a