Cell Cycle Antibodies 1

Anti-SPAG5 Antibody (CAB6451)

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SKU:
CAB6451
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Cycle

Description

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Antibody Name:Anti-SPAG5 Antibody
Antibody SKU:CAB6451
Antibody Size:20uL, 50uL, 100uL
Application:IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SPAG5 (NP_006452.3).
Application:IF
Recommended Dilution:IF 1:20 - 1:50
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SPAG5 (NP_006452.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MWRV KKLS LSLS PSPQ TGKP SMRT PLRE LTLQ PGAL TNSG KRSP ACSS LTPS LCKL GLQE GSNN SSPV DFVN NKRT DLSS EHFS HSSK WLET CQHE SDEQ PLDP IPQI SSTP KTSE EAVD PLGN YMVK TIVL VPSP LGQQ QDMI FEAR LDTM AETN SISL NGPL RTDD LVRE EVAP CMGD RFSE VAAV SEKP IFQE SPSH LLEE SPPN PCSE QLHC SKES LSSR TEAV REDL VPSE SNAF LPSS VLWL SPST ALAA DFRV NHVD PEEE IVEH GAME EREM RFPT HPKE SETE DQAL VSSV
Gene ID:10615
Uniprot:Q96R06
Cellular Location:Chromosome, Cytoplasm, Cytoplasmic granule, Midbody, centriolar satellite, centromere, centrosome, cytoskeleton, kinetochore, microtubule organizing center, spindle, spindle pole
Calculated MW:134kDa
Observed MW:
Synonyms:SPAG5, DEEPEST, MAP126, hMAP126
Background:This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles.
UniProt Protein Function:SPAG5: Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments.
UniProt Protein Details:

Protein type:Cell cycle regulation

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: kinetochore; spindle microtubule

Molecular Function:protein binding

Biological Process: chromosome segregation; establishment of spindle orientation; mitotic sister chromatid segregation; regulation of attachment of spindle microtubules to kinetochore; spindle organization and biogenesis

NCBI Summary:This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles. [provided by RefSeq, Jul 2008]
UniProt Code:Q96R06
NCBI GenInfo Identifier:47117278
NCBI Gene ID:10615
NCBI Accession:Q96R06.2
UniProt Secondary Accession:Q96R06,O95213, Q9BWE8, Q9NT17, Q9UFE6,
UniProt Related Accession:Q96R06
Molecular Weight:134,422 Da
NCBI Full Name:Sperm-associated antigen 5
NCBI Synonym Full Names:sperm associated antigen 5
NCBI Official Symbol:SPAG5  
NCBI Official Synonym Symbols:MAP126; DEEPEST; hMAP126  
NCBI Protein Information:sperm-associated antigen 5
UniProt Protein Name:Sperm-associated antigen 5
UniProt Synonym Protein Names:Astrin; Deepest; Mitotic spindle-associated protein p126; MAP126
Protein Family:Sperm-associated antigen
UniProt Gene Name:SPAG5  
Anti-SPAG5 Antibody (CAB6451)Immunofluorescence analysis of HeLa cells using SPAG5 antibody (CAB6451). Blue: DAPI for nuclear staining.
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