Cell Biology Antibodies 9
Anti-SPA17 Antibody (CAB4769)
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- SKU:
- CAB4769
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- SPA17
- Synonyms:
- CT22
- Synonyms:
- SP17
- Synonyms:
- SP17-1
- Research Area:
- Cell Biology
Description
| Product Name: | SPA17 Rabbit pAb |
| Product Code: | CAB4769 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | SPA17, CT22, SP17, SP17-1 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-151 of human SPA17 (NP_059121.1). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, SW480, THP-1, Mouse testis, Mouse lung, Mouse kidney, Rat testis, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-151 of human SPA17 (NP_059121.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSIP FSNT HYRI PQGF GNLL EGLT REIL REQP DNIP AFAA AYFE SLLE KREK TNFD PAEW GSKV EDRF YNNH AFEE QEPP EKSD PKQE ESQI SGKE EETS VTIL DSSE EDKE KEEV AAVK IQAA FRGH IARE EAKK MKTN SLQN EEKE ENK |
| Gene ID: | 53340 |
| Uniprot: | Q15506 |
| Cellular Location: | Membrane, Peripheral membrane protein |
| Calculated MW: | 17kDa |
| Observed MW: | 17kDa |
| UniProt Protein Function: | SPA17: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates. |
| UniProt Protein Details: | Protein type:Cancer Testis Antigen (CTA) Chromosomal Location of Human Ortholog: 11q24.2 Cellular Component: membrane; cytoplasm Molecular Function:calmodulin binding Biological Process: binding of sperm to zona pellucida; single fertilization; spermatogenesis |
| NCBI Summary: | This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009] |
| UniProt Code: | Q15506 |
| NCBI GenInfo Identifier: | 2833264 |
| NCBI Gene ID: | 53340 |
| NCBI Accession: | Q15506.1 |
| UniProt Secondary Accession: | Q15506,Q9BXF7, B2R4F2, |
| UniProt Related Accession: | Q15506 |
| Molecular Weight: | 151 |
| NCBI Full Name: | Sperm surface protein Sp17 |
| NCBI Synonym Full Names: | sperm autoantigenic protein 17 |
| NCBI Official Symbol: | SPA17 |
| NCBI Official Synonym Symbols: | CT22; SP17; SP17-1 |
| NCBI Protein Information: | sperm surface protein Sp17; sperm protein 17; cancer/testis antigen 22 |
| UniProt Protein Name: | Sperm surface protein Sp17 |
| UniProt Synonym Protein Names: | Cancer/testis antigen 22; CT22; Sp17-1; Sperm autoantigenic protein 17; Sperm protein 17 |
| Protein Family: | Sperm surface protein |
| UniProt Gene Name: | SPA17 |
| UniProt Entry Name: | SP17_HUMAN |
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