Epigenetics & Nuclear Signaling Antibodies 2
Anti-SP4 Antibody (CAB16431)
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- SKU:
- CAB16431
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-SP4 Antibody |
| Antibody SKU: | CAB16431 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 280-440 of human SP4 (NP_003103.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse thymus, Mouse spleen, Mouse pancreas, Rat thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 280-440 of human SP4 (NP_003103.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TGQV GQPA ATAD SGTS NGNQ LVST PTNT TTSA STMP ESPS SSTT CTTT ASTS LTSS DTLV SSAD TGQY ASTS ASSS ERTI EESQ TPAA TESE AQSS SQLQ PNGM QNAQ DQSN SLQQ VQIV GQPI LQQI QIQQ PQQQ IIQA IPPQ SFQL QSGQ TIQT IQQQ P |
| Gene ID: | 6671 |
| Uniprot: | Q02446 |
| Cellular Location: | Nucleus |
| Calculated MW: | 81kDa |
| Observed MW: | 82kDa |
| Synonyms: | SP4, HF1B, SPR-1 |
| Background: | The protein encoded by this gene is a transcription factor that can bind to the GC promoter region of a variety of genes, including those of the photoreceptor signal transduction system. The encoded protein binds to the same sites in promoter CpG islands as does the transcription factor SP1, although its expression is much more restricted compared to that of SP1. This gene may be involved in bipolar disorder and schizophrenia. |
| UniProt Protein Function: | SP4: Binds to GT and GC boxes promoters elements. Probable transcriptional activator. Belongs to the Sp1 C2H2-type zinc-finger protein family. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding; C2H2-type zinc finger protein Chromosomal Location of Human Ortholog: 7p15.3 Cellular Component: microtubule cytoskeleton; nucleoplasm; intercellular bridge; cytoplasm Molecular Function:DNA binding; metal ion binding; transcription coactivator activity Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; regulation of heart contraction |
| UniProt Code: | Q02446 |
| NCBI GenInfo Identifier: | 218511800 |
| NCBI Gene ID: | 6671 |
| NCBI Accession: | Q02446.2 |
| UniProt Secondary Accession: | Q02446,Q62445, |
| UniProt Related Accession: | Q02446 |
| Molecular Weight: | 81,985 Da |
| NCBI Full Name: | Transcription factor Sp4 |
| NCBI Synonym Full Names: | Sp4 transcription factor |
| NCBI Official Symbol: | SP4 |
| NCBI Official Synonym Symbols: | HF1B; SPR-1 |
| NCBI Protein Information: | transcription factor Sp4 |
| UniProt Protein Name: | Transcription factor Sp4 |
| UniProt Synonym Protein Names: | SPR-1 |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | SP4 |
| UniProt Entry Name: | SP4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SP4 antibody (CAB16431) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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