Cell Biology Antibodies 13

Anti-SP140 Antibody (CAB17634)

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SKU:
CAB17634
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-SP140 Antibody
Antibody SKU:CAB17634
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human SP140 (NP_001265380).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse spleen, Mouse thymus, Rat thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human SP140 (NP_001265380).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAQQ GQQG QMAS GDSN LNFR MVAE IQNV EGQN LQEQ VCPE PIFR FFRE NKVE IASA ITRP FPFL MGLR DRSF ISEQ MYEH FQEA FRNL VPVT RVMY CVLS ELEK TFGW SHLE ALFS RINL MAYP DLNE IYRS FQNV CYEH SPLQ MNNV NDLE DRPR LLPY GKQE NSNA CHEM DDIA VPQE
Gene ID:11262
Uniprot:Q13342
Cellular Location:
Calculated MW:
Observed MW:98kDa
Anti-SP140 Antibody (CAB17634)Western blot - SP140 Polyclonal Antibody (CAB17634)
Synonyms:LYSP100, LYSP100-A, LYSP100-B, SP140
Background:This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016]
UniProt Protein Function:SP140: Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: nucleoplasm; PML body; cytoplasm; nuclear envelope; nucleus

Molecular Function:protein binding; DNA binding; zinc ion binding; chromatin binding; transcription factor activity

Biological Process: chromatin remodeling; regulation of transcription, DNA-dependent; defense response

UniProt Code:Q13342
NCBI GenInfo Identifier:217330601
NCBI Gene ID:11262
NCBI Accession:NP_009168.4
UniProt Secondary Accession:Q13342,Q0VGE5, Q13341, Q3KR17, Q4ZG66, Q53TG1, Q6NSG4 Q92881, Q96TG3, E7ESH9, E7EUR5, E9PFJ6,
UniProt Related Accession:Q13342
Molecular Weight:91,673 Da
NCBI Full Name:nuclear body protein SP140 isoform 1
NCBI Synonym Full Names:SP140 nuclear body protein
NCBI Official Symbol:SP140  
NCBI Official Synonym Symbols:LYSP100; LYSP100-A; LYSP100-B  
NCBI Protein Information:nuclear body protein SP140; speckled 140 kDa; nuclear autoantigen Sp-140; lymphoid-specific SP100 homolog; lymphoid-restricted homolog of Sp100
UniProt Protein Name:Nuclear body protein SP140
UniProt Synonym Protein Names:Lymphoid-restricted homolog of Sp100; Nuclear autoantigen Sp-140; Speckled 140 kDa
Protein Family:Nuclear body protein
UniProt Gene Name:SP140  
UniProt Entry Name:SP140_HUMAN
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