Immunology Antibodies 2
Anti-SP110 Antibody (CAB7492)
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- SKU:
- CAB7492
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-SP110 Antibody |
| Antibody SKU: | CAB7492 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human SP110 (NP_004501.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | NCI-H460, Jurkat, HeLa, Mouse heart, Mouse thymus, Mouse ovary, Mouse liver, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human SP110 (NP_004501.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MFTM TRAM EEAL FQHF MHQK LGIA YAIH KPFP FFEG LLDN SIIT KRMY MESL EACR NLIP VSRV VHNI LTQL ERTF NLSL LVTL FSQI NLRE YPNL VTIY RSFK RVGA SYER QSRD TPIL LEAP TGLA EGSS LHTP LALP PPQP PQPS CSPC APRV SEPG TSSQ QSDE ILSE SPSP SDPV LPLP ALIQ EGRS TSVT NDKL TSKM NAEE DSEE MPSL LTST VQVA SDNL IPQI RDKE DPQE MPHS PLGS MPEI RDNS PEPN DPEE PQEV SSTP SDKK GKKR KRCI WSTP KR |
| Gene ID: | 3431 |
| Uniprot: | Q9HB58 |
| Cellular Location: | Nucleus |
| Calculated MW: | 28kDa/46kDa/61kDa/62kDa/78kDa/81kDa |
| Observed MW: | 78kDa |
| Synonyms: | SP110, IFI41, IFI75, IPR1, VODI |
| Background: | The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. |
| UniProt Protein Function: | SP110: Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE). Defects in SP110 are the cause of hepatic venoocclusive disease with immunodeficiency (VODI). VODI is an autosomal recessive primary immunodeficiency associated with hepatic vascular occlusion and fibrosis. The immunodeficiency is characterized by severe hypogammaglobulinemia, combined T and B cell immunodeficiency, absent lymph node germinal centers, and absent tissue plasma cells. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 2q37.1 Cellular Component: nucleolus; nucleus Molecular Function:signal transducer activity; DNA binding; zinc ion binding; chromatin binding Biological Process: chromatin remodeling; transcription, DNA-dependent; viral reproduction; regulation of transcription, DNA-dependent; signal transduction Disease: Mycobacterium Tuberculosis, Susceptibility To; Hepatic Venoocclusive Disease With Immunodeficiency |
| UniProt Code: | Q9HB58 |
| NCBI GenInfo Identifier: | 313104323 |
| NCBI Gene ID: | |
| NCBI Accession: | Q9HB58.5 |
| Molecular Weight: | 78kDa |
| NCBI Full Name: | Sp110 nuclear body protein |
| UniProt Protein Name: | Sp110 nuclear body protein |
| UniProt Synonym Protein Names: | Interferon-induced protein 41/75; Speckled 110 kDa; Transcriptional coactivator Sp110 |
| Protein Family: | Sp110 nuclear body protein |
| UniProt Gene Name: | SP110 |
| UniProt Entry Name: | SP110_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SP110 antibody (CAB7492) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 30s. |
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