Epigenetics & Nuclear Signaling Antibodies 2

Anti-SOX7 Antibody (CAB14941)

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SKU:
CAB14941
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-SOX7 Antibody
Antibody SKU:CAB14941
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 250-350 of human SOX7 (NP_113627.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse heart
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 250-350 of human SOX7 (NP_113627.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PLHC SHPL GSLA LGQS PGVS MMSP VPGC PPSP AYYS PATY HPLH SNLQ AHLG QLSP PPEH PGFD ALDQ LSQV ELLG DMDR NEFD QYLN TPGH PDSA TGAM A
Gene ID:83595
Uniprot:Q9BT81
Cellular Location:Cytoplasm, Nucleus
Calculated MW:42kDa/48kDa
Observed MW:42kDa
Synonyms:SOX7, SRY-box 7
Background:This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway.
UniProt Protein Function:SOX7: Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors. May be required for the survival of both hematopoietic and endothelial precursors during specification. Competes with GATA4 for binding and activation of the FGF3 promoter. Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'- AACAAT-3'.
UniProt Protein Details:

Protein type:Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: cytoplasm; nucleus

Molecular Function:RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription factor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; negative regulation of cell proliferation; endoderm formation; positive regulation of transcription, DNA-dependent; positive regulation of caspase activity; negative regulation of transcription, DNA-dependent

NCBI Summary:This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway. [provided by RefSeq, Jul 2008]
UniProt Code:Q9BT81
NCBI GenInfo Identifier:20532272
NCBI Gene ID:83595
NCBI Accession:Q9BT81.1
UniProt Related Accession:Q9BT81
Molecular Weight:
NCBI Full Name:Transcription factor SOX-7
NCBI Synonym Full Names:SRY-box transcription factor 7
NCBI Official Symbol:SOX7  
NCBI Protein Information:transcription factor SOX-7
UniProt Protein Name:Transcription factor SOX-7
Protein Family:Transcription factor
UniProt Gene Name:SOX7  
UniProt Entry Name:SOX7_HUMAN
Anti-SOX7 Antibody (CAB14941)Western blot analysis of extracts of mouse heart, using SOX7 antibody (CAB14941) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s.
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