Antibody Name:	Anti-SOX5 Antibody
Antibody SKU:	CAB6985
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human SOX5 (NP_694534.1).

Application:	WB IHC IF
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100
Reactivity:	Human, Mouse, Rat
Positive Samples:	HepG2, SH-SY5Y, U-87MG, Mouse heart

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human SOX5 (NP_694534.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MSSK RPAS PYGE ADGE VAMV TSRQ KVEE EESD GLPA FHLP LHVS FPNK PHSE EFQP VSLL TQET CGHR TPTS QHNT MEVD GNKV MSSF APHN SSTS PQKA EEGG RQSG ESLS STAL GTPE
Gene ID:	6660
Uniprot:	P35711
Cellular Location:	Nucleus
Calculated MW:	41kDa/71kDa/82kDa/84kDa
Observed MW:	70kDa

Synonyms:

SOX5, L-SOX5, L-SOX5B, L-SOX5F, LAMSHF, SRY-box 5

Background:

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

UniProt Protein Function:	SOX5: Binds specifically to the DNA sequence 5'-AACAAT-3'. Activates transcription of COL2A1 and AGC1 in vitro. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 12p12.1 Molecular Function:protein binding; protein heterodimerization activity; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; central nervous system neuron differentiation; cell fate commitment; positive regulation of chondrocyte differentiation; in utero embryonic development; cartilage development; regulation of timing of neuron differentiation; oligodendrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
NCBI Summary:	This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:	P35711
NCBI GenInfo Identifier:	30179883
NCBI Gene ID:	6660
NCBI Accession:	P35711.3
UniProt Related Accession:	P35711
Molecular Weight:	~ 70kDa
NCBI Full Name:	Transcription factor SOX-5
NCBI Synonym Full Names:	SRY-box transcription factor 5
NCBI Official Symbol:	SOX5
NCBI Official Synonym Symbols:	L-SOX5; LAMSHF; L-SOX5B; L-SOX5F
NCBI Protein Information:	transcription factor SOX-5
UniProt Protein Name:	Transcription factor SOX-5
Protein Family:	Transcription factor
UniProt Gene Name:	SOX5
UniProt Entry Name:	SOX5_HUMAN

	Immunohistochemistry of paraffin-embedded rat kidney using SOX5 antibody (CAB6985) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human kidney cancer using SOX5 antibody (CAB6985) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse brain using SOX5 antibody (CAB6985) at dilution of 1:100 (40x lens).
	Immunofluorescence analysis of MCF7 cells using SOX5 antibody (CAB6985).