Epigenetics & Nuclear Signaling Antibodies 1
Anti-SOX4 Antibody (CAB10717)
- SKU:
- CAB10717
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-SOX4 Antibody |
| Antibody SKU: | CAB10717 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SOX4 (NP_003098.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SOX4 (NP_003098.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MVQQ TNNA ENTE ALLA GESS DSGA GLEL GIAS SPTP GSTA STGG KADD PSWC KTPS GHIK RPMN AFMV WSQI ERRK IMEQ SPDM HNAE ISKR LGKR WKLL |
| Gene ID: | 6659 |
| Uniprot: | Q06945 |
| Cellular Location: | Nucleus |
| Calculated MW: | 47kDa |
| Observed MW: | 47kDa |
| Synonyms: | SOX4, EVI16, SRY-box 4 |
| Background: | This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. |
| UniProt Protein Function: | SOX4: Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 6p22.3 Cellular Component: cytoplasm; mitochondrion; nucleoplasm; nucleus Molecular Function:protein binding; transcription factor activity Biological Process: DNA damage response, detection of DNA damage; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; glial cell development; glial cell proliferation; glucose homeostasis; heart development; limb bud formation; negative regulation of cell proliferation; negative regulation of protein export from nucleus; negative regulation of protein ubiquitination; neural tube formation; positive regulation of apoptosis; positive regulation of cell proliferation; positive regulation of insulin secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of translation; positive regulation of Wnt receptor signaling pathway; pro-B cell differentiation; protein stabilization; regulation of protein stability; regulation of transcription, DNA-dependent; skeletal development; spinal cord development; spinal cord motor neuron differentiation; sympathetic nervous system development; T cell differentiation; Wnt receptor signaling pathway through beta-catenin |
| NCBI Summary: | This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q06945 |
| NCBI GenInfo Identifier: | 548952 |
| NCBI Gene ID: | 6659 |
| NCBI Accession: | Q06945.1 |
| UniProt Related Accession: | Q06945 |
| Molecular Weight: | 47,263 Da |
| NCBI Full Name: | Transcription factor SOX-4 |
| NCBI Synonym Full Names: | SRY-box 4 |
| NCBI Official Symbol: | SOX4 |
| NCBI Official Synonym Symbols: | EVI16 |
| NCBI Protein Information: | transcription factor SOX-4 |
| UniProt Protein Name: | Transcription factor SOX-4 |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | SOX4 |
| UniProt Entry Name: | SOX4_HUMAN |
 | Western blot analysis of extracts of SW620 cells, using SOX4 antibody (CAB10717) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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