Epigenetics & Nuclear Signaling Antibodies 2
Anti-SOX18 Antibody (CAB16536)
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- SKU:
- CAB16536
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-SOX18 Antibody |
| Antibody SKU: | CAB16536 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SOX18 (NP_060889.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SOX18 (NP_060889.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MQRS PPGY GAQD DPPA RRDC AWAP GHGA AADT RGLA AGPA ALAA PAAP ASPP SPQR SPPR SPEP GRYG LSPA GRGE RQAA DESR IRRP MNAF MVWA KDER |
| Gene ID: | 54345 |
| Uniprot: | P35713 |
| Cellular Location: | Nucleus |
| Calculated MW: | 40kDa |
| Observed MW: | Refer to figures |
| Synonyms: | SOX18, HLTRS, HLTS |
| Background: | This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia. |
| UniProt Protein Function: | SOX18: Binds to the consensus sequence 5'-AACAAAG-3' and is able to trans-activate transcription via this site. Defects in SOX18 are the cause of hypotrichosis- lymphedema-telangiectasia syndrome (HLTS). |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 20q13.33 Cellular Component: nuclear chromatin; nucleus Biological Process: angiogenesis; blood vessel endothelial cell migration; embryonic heart tube development; hair cycle process; heart looping; lymphangiogenesis; mRNA transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; vasculature development; vasculogenesis Disease: Hypotrichosis-lymphedema-telangiectasia Syndrome; Hypotrichosis-lymphedema-telangiectasia-renal Defect Syndrome |
| NCBI Summary: | This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P35713 |
| NCBI GenInfo Identifier: | 12644232 |
| NCBI Gene ID: | 54345 |
| NCBI Accession: | P35713.2 |
| UniProt Secondary Accession: | P35713,Q0VGA9, Q9NPH8, |
| UniProt Related Accession: | P35713 |
| Molecular Weight: | 40,891 Da |
| NCBI Full Name: | Transcription factor SOX-18 |
| NCBI Synonym Full Names: | SRY-box 18 |
| NCBI Official Symbol: | SOX18 |
| NCBI Official Synonym Symbols: | HLTS; HLTRS |
| NCBI Protein Information: | transcription factor SOX-18 |
| UniProt Protein Name: | Transcription factor SOX-18 |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | SOX18 |
| UniProt Entry Name: | SOX18_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SOX18 antibody (CAB16536) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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