Anti-SOX17 Antibody (CAB18858)
- SKU:
- CAB18858
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- VUR3
Description
| Product Name: | SOX17 Rabbit pAb |
| Product Code: | CAB18858 |
| Size: | 50uL, 100uL |
| Synonyms: | VUR3 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human SOX17. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, Mouse lung, Mouse testis, Mouse kidney, Rat kidney, Rat uterus |
| Immunogen: | Recombinant protein of human SOX17. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 64321 |
| Uniprot: | Q9H6I2 |
| Observed MW: | 50KDa |
| UniProt Protein Function: | SOX17: Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'- AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells. Defects in SOX17 are the cause of vesicoureteral reflux type 3 (VUR3). VUR3 is a disease belonging to the group of congenital anomalies of the kidney and urinary tract. It is characterized by the reflux of urine from the bladder into the ureters and sometimes into the kidneys, and is a risk factor for urinary tract infections. Primary disease results from a developmental defect of the ureterovesical junction. In combination with intrarenal reflux, the resulting inflammatory reaction may result in renal injury or scarring, also called reflux nephropathy. Extensive renal scarring impairs renal function and may predispose patients to hypertension, proteinuria, renal insufficiency and end-stage renal disease. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription regulation Chromosomal Location of Human Ortholog: 8q11.23 Cellular Component: nucleoplasm; nucleus; transcription factor complex Molecular Function:beta-catenin binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; transcription factor binding Biological Process: angiogenesis; embryonic foregut morphogenesis; embryonic heart tube development; endoderm formation; heart looping; mRNA transcription from RNA polymerase II promoter; negative regulation of cell growth; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein destabilization; protein stabilization; regulation of embryonic development; regulation of transcription, DNA-dependent; vasculogenesis Disease: Vesicoureteral Reflux 3 |
| NCBI Summary: | This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9H6I2 |
| NCBI GenInfo Identifier: | 23822216 |
| NCBI Gene ID: | 64321 |
| NCBI Accession: | Q9H6I2.1 |
| UniProt Related Accession: | Q9H6I2 |
| Molecular Weight: | 44,117 Da |
| NCBI Full Name: | Transcription factor SOX-17 |
| NCBI Synonym Full Names: | SRY-box 17 |
| NCBI Official Symbol: | SOX17 |
| NCBI Official Synonym Symbols: | VUR3 |
| NCBI Protein Information: | transcription factor SOX-17 |
| UniProt Protein Name: | Transcription factor SOX-17 |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | SOX17 |
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