Epigenetics & Nuclear Signaling Antibodies 4

Anti-SOX14 Antibody (CAB7217)

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SKU:
CAB7217
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-SOX14 Antibody
Antibody SKU:CAB7217
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 91-240 of human SOX14 (NP_004180.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 91-240 of human SOX14 (NP_004180.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RYVF PLPY LGDT DPLK AAGL PVGA SDGL LSAP EKAR AFLP PASA PYSL LDPA QFSS SAIQ KMGE VPHT LATG ALPY ASTL GYQN GAFG SLSC PSQH THTH PSPT NPGY VVPC NCTA WSAS TLQP PVAY ILFP GMTK TGID PYSS AHAT AM
Gene ID:8403
Uniprot:O95416
Cellular Location:Nucleus
Calculated MW:26kDa
Observed MW:26kDa
Synonyms:SOX14, SOX28
Background:This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene are suggested to be responsible for the limb defects associated with blepharophimosis, ptosis, epicanthus inversus syndrome (BPES) and Mobius syndrome.
UniProt Protein Function:SOX14: Acts as a negative regulator of transcription.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 3q22-q23

Molecular Function:protein heterodimerization activity; sequence-specific DNA binding; chromatin binding

Biological Process: transcription from RNA polymerase II promoter; nervous system development; visual perception; entrainment of circadian clock; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent

NCBI Summary:This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene are suggested to be responsible for the limb defects associated with blepharophimosis, ptosis, epicanthus inversus syndrome (BPES) and Mobius syndrome. [provided by RefSeq, Jul 2008]
UniProt Code:O95416
NCBI GenInfo Identifier:6831689
NCBI Gene ID:8403
NCBI Accession:O95416.1
UniProt Secondary Accession:O95416,Q3KPH7, B2RAC0,
UniProt Related Accession:O95416
Molecular Weight:240
NCBI Full Name:Transcription factor SOX-14
NCBI Synonym Full Names:SRY (sex determining region Y)-box 14
NCBI Official Symbol:SOX14  
NCBI Official Synonym Symbols:SOX28  
NCBI Protein Information:transcription factor SOX-14; SRY-box 14; HMG box transcription factor SOX-14
UniProt Protein Name:Transcription factor SOX-14
UniProt Synonym Protein Names:Protein SOX-28
Protein Family:Transcription factor
UniProt Gene Name:SOX14  
UniProt Entry Name:SOX14_HUMAN
Anti-SOX14 Antibody (CAB7217)Western blot analysis of extracts of various cell lines, using SOX14 antibody (CAB7217) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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