Developmental Biology
Anti-SOX13 Antibody (CAB15759)
- SKU:
- CAB15759
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-SOX13 Antibody |
| Antibody SKU: | CAB15759 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human SOX13 (NP_005677.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | LO2, HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human SOX13 (NP_005677.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSMR SPIS AQLA LDGV GTMV NCTI KSEE KKEP CHEA PQGS ATAA EPQP GDPA RASQ DSAD PQAP AQGN FRGS WDCS SPEG NGSP EPKR PGVS EAAS GSQE KLDF NRNL KEVV PAIE KLLS SDWK ERFL GRNS MEAK DVKG TQES LAEK ELQL LVMI HQLS TLRD QLLT AHSE QKNM AAML |
| Gene ID: | 9580 |
| Uniprot: | Q9UN79 |
| Cellular Location: | Nucleus |
| Calculated MW: | 69kDa |
| Observed MW: | 114kDa |
| Synonyms: | SOX13, ICA12, Sox-13 |
| Background: | This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. It has also been determined to be a type-1 diabetes autoantigen, also known as islet cell antibody 12. |
| UniProt Protein Function: | SP1: a transcription factor of the Sp1 C2H2-type zinc-finger protein family. Phosphorylated and activated by MAPK. Dephosphorylation by PTEN inhibits DNA binding. Binds to p38 in the nucleus. Interacts with Huntingtin and TAFII130. Transcriptional activity of SP1 and TAFII130 disrupted in early Huntingtin's Disease. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor; C2H2-type zinc finger protein Chromosomal Location of Human Ortholog: 12q13.1 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:protein C-terminus binding; histone acetyltransferase binding; protein binding; protein homodimerization activity; DNA binding; sequence-specific DNA binding; metal ion binding; histone deacetylase binding; double-stranded DNA binding; bHLH transcription factor binding; transcription factor binding; transcription factor activity Biological Process: transcription initiation from RNA polymerase II promoter; ossification; embryonic placenta development; transcription, DNA-dependent; viral reproduction; megakaryocyte differentiation; embryonic skeletal development; positive regulation of transcription, DNA-dependent; embryonic process involved in female pregnancy; rhythmic process; cellular lipid metabolic process; enucleate erythrocyte differentiation; liver development; trophectodermal cell differentiation; regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; gene expression; positive regulation of transcription from RNA polymerase II promoter; embryonic camera-type eye morphogenesis; lung development |
| UniProt Code: | Q9UN79 |
| NCBI GenInfo Identifier: | 41406089 |
| NCBI Gene ID: | 9580 |
| NCBI Accession: | NP_005677 |
| UniProt Secondary Accession: | Q9UN79,O95275, O95826, Q3KQV7, Q5SXX1, Q9UHW7, B4E2B0 |
| UniProt Related Accession: | Q9UN79 |
| Molecular Weight: | 69,228 Da |
| NCBI Full Name: | transcription factor SOX-13 |
| NCBI Synonym Full Names: | SRY (sex determining region Y)-box 13 |
| NCBI Official Symbol: | SOX13 |
| NCBI Official Synonym Symbols: | ICA12; Sox-13 |
| NCBI Protein Information: | transcription factor SOX-13; SRY-box 13; SRY-related HMG-box gene 13; islet cell antibody 12; islet cell antigen 12; type 1 diabetes autoantigen ICA12 |
| UniProt Protein Name: | Transcription factor Sp1 |
| Protein Family: | Sp110 nuclear body protein |
| UniProt Gene Name: | SP1 |
| UniProt Entry Name: | SP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SOX13 antibody (CAB15759) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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