Metabolism Antibodies 2

Anti-SOSTDC1 Antibody (CAB16315)

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SKU:
CAB16315
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-SOSTDC1 Antibody
Antibody SKU:CAB16315
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 115-206 of human SOSTDC1 (NP_056279.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, Mouse brian, Mouse kidney, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 115-206 of human SOSTDC1 (NP_056279.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GGGY GTKY WSRR SSQE WRCV NDKT RTQR IQLQ CQDG STRT YKIT VVTA CKCK RYTR QHNE SSHN FESM SPAK PVQH HRER KRAS KSSK HSMS
Gene ID:25928
Uniprot:Q6X4U4
Cellular Location:
Calculated MW:23kDa/26kDa
Observed MW:26kDa
Synonyms:SOSTDC1, CDA019, DAND7, ECTODIN, USAG1
Background:This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.
UniProt Protein Function:SOSTDC1: May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling. Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. Belongs to the sclerostin family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7p21.1

NCBI Summary:This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [provided by RefSeq, Jul 2008]
UniProt Code:Q6X4U4
NCBI GenInfo Identifier:62287504
NCBI Gene ID:25928
NCBI Accession:Q6X4U4.2
UniProt Secondary Accession:Q6X4U4,Q96HJ7, Q9Y3U3, A8MUA6,
UniProt Related Accession:Q6X4U4
Molecular Weight:26,260 Da
NCBI Full Name:Sclerostin domain-containing protein 1
NCBI Synonym Full Names:sclerostin domain containing 1
NCBI Official Symbol:SOSTDC1  
NCBI Official Synonym Symbols:DAND7; USAG1; CDA019; ECTODIN  
NCBI Protein Information:sclerostin domain-containing protein 1
UniProt Protein Name:Sclerostin domain-containing protein 1
UniProt Synonym Protein Names:Ectodermal BMP inhibitor; Ectodin; Uterine sensitization-associated gene 1 protein; USAG-1
Protein Family:Sclerostin domain-containing protein
UniProt Gene Name:SOSTDC1  
UniProt Entry Name:SOSD1_HUMAN
Anti-SOSTDC1 Antibody (CAB16315)Western blot analysis of extracts of various cell lines, using SOSTDC1 antibody (CAB16315) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min.
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