Name: Anti-SORL1 Antibody (CAB13047)
Brand: Cell Biology Antibodies 3
SKU: CAB13047
Availability: OutOfStock

Antibody Name:	Anti-SORL1 Antibody
Antibody SKU:	CAB13047
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 2065-2214 of human SORL1 (NP_003096.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:	SH-SY5Y, HepG2

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 2065-2214 of human SORL1 (NP_003096.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	DSAM NITA YLGN TTDN FFKI SNLK MGHN YTFT VQAR CLFG NQIC GEPA ILLY DELG SGAD ASAT QAAR STDV AAVV VPIL FLIL LSLG VGFA ILYT KHRR LQSS FTAF ANSH YSSR LGSA IFSS GDDL GEDD EDAP MITG FSDD VPMV IA
Gene ID:	6653
Uniprot:	Q92673
Cellular Location:	Endosome, Golgi apparatus, Membrane, Secreted, Single-pass type I membrane protein
Calculated MW:	248kDa
Observed MW:	290kDa

Synonyms:

SORL1, C11orf32, LR11, LRP9, SORLA, SorLA-1, gp250

Background:

This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded preproprotein is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting. Mutations in this gene may be associated with Alzheimer's disease.

UniProt Protein Function:	SORL1: Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction. Belongs to the VPS10-related sortilin family. SORL1 subfamily.
UniProt Protein Details:	Protein type:Cell surface; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 11q24.1 Cellular Component: early endosome; endoplasmic reticulum; endosome; extracellular space; Golgi apparatus; Golgi cisterna; integral to plasma membrane; membrane; nuclear envelope lumen; recycling endosome; trans-Golgi network Molecular Function:ADP-ribosylation factor binding; beta-amyloid binding; low-density lipoprotein binding; protein binding; transmembrane receptor activity Biological Process: negative regulation of MAP kinase activity; negative regulation of neurogenesis; negative regulation of protein binding; negative regulation of protein oligomerization; positive regulation of protein catabolic process; post-Golgi vesicle-mediated transport; protein maturation; protein retention in Golgi; protein targeting; protein targeting to Golgi; protein targeting to lysosome; receptor-mediated endocytosis; regulation of smooth muscle cell migration Disease: Alzheimer Disease
NCBI Summary:	This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded preproprotein is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting. Mutations in this gene may be associated with Alzheimer's disease. [provided by RefSeq, Feb 2016]
UniProt Code:	Q92673
NCBI GenInfo Identifier:	649105467
NCBI Gene ID:	6653
NCBI Accession:	AIC50396.1
UniProt Secondary Accession:	Q92673,Q92856, B2RNX7,
UniProt Related Accession:	Q92673
Molecular Weight:	44.2
NCBI Full Name:	WTAP, partial
NCBI Synonym Full Names:	sortilin related receptor 1
NCBI Official Symbol:	SORL1
NCBI Official Synonym Symbols:	LR11; LRP9; SORLA; gp250; SorLA-1; C11orf32
NCBI Protein Information:	sortilin-related receptor
UniProt Protein Name:	Sortilin-related receptor
UniProt Synonym Protein Names:	Low-density lipoprotein receptor relative with 11 ligand-binding repeats; LDLR relative with 11 ligand-binding repeats; LR11; SorLA-1; Sorting protein-related receptor containing LDLR class A repeats; SorLA
Protein Family:	Pre-mRNA-splicing regulator
UniProt Gene Name:	SORL1

Western blot analysis of extracts of various cell lines, using SORL1 antibody (CAB13047) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.

ELISA Kits

Human SorLA / SORL1 ELISA Kit

Human Sortilin-related receptor (SORL1) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)