Cell Biology Antibodies 4
Anti-SOD3 Antibody (CAB13935)
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- SKU:
- CAB13935
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SOD3 Antibody |
| Antibody SKU: | CAB13935 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-160 of human SOD3 (NP_003093.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse lung, Mouse kidney, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-160 of human SOD3 (NP_003093.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | WTGE DSAE PNSD SAEW IRDM YAKV TEIW QEVM QRRD DDGA LHAA CQVQ PSAT LDAA QPRV TGVV LFRQ LAPR AKLD AFFA LEGF PTEP NSSS RAIH VHQF GDLS QGCE STGP HYNP LAVP HPQH PGDF GNFA VRDG SLWR YR |
| Gene ID: | 6649 |
| Uniprot: | P08294 |
| Cellular Location: | Secreted, extracellular space |
| Calculated MW: | 25kDa |
| Observed MW: | 26kDa |
| Synonyms: | SOD3, EC-SOD |
| Background: | This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. |
| UniProt Protein Function: | SOD3: Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen. Belongs to the Cu-Zn superoxide dismutase family. |
| UniProt Protein Details: | Protein type:EC 1.15.1.1; Secreted, signal peptide; Oxidoreductase; Secreted Chromosomal Location of Human Ortholog: 4p15.2 Cellular Component: extracellular matrix; extracellular space; Golgi lumen; cytoplasm; extracellular region; trans-Golgi network; nucleus Molecular Function:heparin binding; protein binding; copper ion binding; zinc ion binding; superoxide dismutase activity Biological Process: response to reactive oxygen species; response to copper ion; removal of superoxide radicals; response to hypoxia |
| NCBI Summary: | This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015] |
| UniProt Code: | P08294 |
| NCBI GenInfo Identifier: | 108885292 |
| NCBI Gene ID: | 6649 |
| NCBI Accession: | P08294.2 |
| UniProt Related Accession: | P08294 |
| Molecular Weight: | |
| NCBI Full Name: | Extracellular superoxide dismutase |
| NCBI Synonym Full Names: | superoxide dismutase 3 |
| NCBI Official Symbol: | SOD3 |
| NCBI Official Synonym Symbols: | EC-SOD |
| NCBI Protein Information: | extracellular superoxide dismutase [Cu-Zn] |
| UniProt Protein Name: | Extracellular superoxide dismutase [Cu-Zn] |
| Protein Family: | Sodium channel |
| UniProt Gene Name: | SOD3 |
| UniProt Entry Name: | SODE_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SOD3 Rabbit pAb (CAB13935) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of U2OS cells using SOD3 antibody (CAB13935). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of PC-12 cells using SOD3 antibody (CAB13935) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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