Description
Antibody Name: | Anti-SOCS1 Antibody (CAB20838) |
Antibody SKU: | CAB20838 |
Antibody Size: | 50µL, 100µL |
Application: | Immunohistochemistry, Immunofluorescence |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SOCS1 (NP_003736.1). |
Application: | Immunohistochemistry, Immunofluorescence |
Recommended Dilution: | IHC 1:50 - 1:200 IF 1:50 - 1:200 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SOCS1 (NP_003736.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | MVAH NQVA ADNA VSTA AEPR RRPE PSSS SSSS PAAP ARPR PCPA VPAP APGD THFR TFRS HADY RRIT RASA LLDA CGFY WGPL SVHG AHER LRAE PVGT |
Cellular Location: | Cytoplasmic vesicle, Nucleus |
Calculated MW: | 23kDa |
Observed MW: | Refer to figures |
Synonyms: | SOCS1, CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3, TIP-3 |
Background: | This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. |
Immunofluorescence analysis of MCF7 cells using SOCS1 Rabbit mAb at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. | |
Immunohistochemistry of paraffin-embedded rat lung using SOCS1 Rabbit mAb at dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with IHC staining protocol. | |
Immunohistochemistry of paraffin-embedded human colon using SOCS1 Rabbit mAb at dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with IHC staining protocol. | |
Immunohistochemistry of paraffin-embedded mouse stomach using SOCS1 Rabbit mAb at dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with IHC staining protocol. | |
Immunohistochemistry of paraffin-embedded human colon carcinoma using SOCS1 Rabbit mAb at dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with IHC staining protocol. |