Cell Cycle Antibodies 1

Anti-SNX9 Antibody (CAB0977)

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SKU:
CAB0977
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Cycle

Description

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Antibody Name:Anti-SNX9 Antibody
Antibody SKU:CAB0977
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human SNX9 (NP_057308.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:A375, HeLa, Mouse liver, Rat liver, Rat heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human SNX9 (NP_057308.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MATK ARVM YDFA AEPG NNEL TVNE GEII TITN PDVG GGWL EGRN IKGE RGLV PTDY VEIL PSDG KDQF SCGN SVAD QAFL DSLS ASTA QASS SAAS NNHQ VGSG NDPW SAWS ASKS GNWE SSEG WGAQ PEGA GAQR NTNT PNNW DTAF GHPQ AYQG PATG DDDD WDED WDGP KSSS YFKD SESA DAGG AQRG NSRA SSSS MKIP LNKF PG
Gene ID:51429
Uniprot:Q9Y5X1
Cellular Location:Cell membrane, Cell projection, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Cytoplasmic vesicle membrane, Golgi apparatus, Peripheral membrane protein, clathrin-coated vesicle, ruffle, trans-Golgi network
Calculated MW:66kDa
Observed MW:90kDa
Synonyms:SNX9, SDP1, SH3PX1, SH3PXD3A, WISP
Background:This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region, like some family members, but does contain a SRC homology domain near its N-terminus. The encoded protein is reported to have a variety of interaction partners, including of adaptor protein 2 , dynamin, tyrosine kinase non-receptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded protein is implicated in several stages of intracellular trafficking, including endocytosis, macropinocytosis, and F-actin nucleation.
UniProt Protein Function:SNX9: May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F- actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. Belongs to the sorting nexin family.
UniProt Protein Details:

Protein type:Vesicle

Chromosomal Location of Human Ortholog: 6q25.3

Cellular Component: ruffle; extrinsic to internal side of plasma membrane; cytoplasmic vesicle membrane; clathrin-coated vesicle; cytoplasmic membrane-bound vesicle; cytoplasm; plasma membrane; trans-Golgi network; endosome

Molecular Function:protein binding; protein homodimerization activity; ubiquitin protein ligase binding; phosphoinositide binding; phosphatidylinositol binding

Biological Process: mitosis; intracellular protein transport; receptor-mediated endocytosis; positive regulation of protein oligomerization; cytokinesis after mitosis; positive regulation of protein kinase activity; vesicle organization and biogenesis; endocytosis; endosome transport; positive regulation of membrane protein ectodomain proteolysis; positive regulation of GTPase activity

NCBI Summary:This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region, like some family members, but does contain a SRC homology domain near its N-terminus. The encoded protein is reported to have a variety of interaction partners, including of adaptor protein 2 , dynamin, tyrosine kinase non-receptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded protein is implicated in several stages of intracellular trafficking, including endocytosis, macropinocytosis, and F-actin nucleation. [provided by RefSeq, Jul 2013]
UniProt Code:Q9Y5X1
NCBI GenInfo Identifier:12643956
NCBI Gene ID:51429
NCBI Accession:Q9Y5X1.1
UniProt Secondary Accession:Q9Y5X1,Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20,
UniProt Related Accession:Q9Y5X1
Molecular Weight:595
NCBI Full Name:Sorting nexin-9
NCBI Synonym Full Names:sorting nexin 9
NCBI Official Symbol:SNX9  
NCBI Official Synonym Symbols:SDP1; WISP; SH3PX1; SH3PXD3A  
NCBI Protein Information:sorting nexin-9; SH3 and PX domain-containing protein 1; SH3 and PX domain-containing protein 3A; Wiskott-Aldrich syndrome protein (WASP) interactor protein
UniProt Protein Name:Sorting nexin-9
UniProt Synonym Protein Names:SH3 and PX domain-containing protein 1; Protein SDP1; SH3 and PX domain-containing protein 3A
Protein Family:Sorting nexin
UniProt Gene Name:SNX9  
UniProt Entry Name:SNX9_HUMAN
Anti-SNX9 Antibody (CAB0977)Western blot analysis of extracts of various cell lines, using SNX9 antibody (CAB0977) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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