Name: Anti-SNX6 Antibody (CAB10039)
Brand: Cell Biology Antibodies 1
SKU: CAB10039
Availability: OutOfStock

Antibody Name:	Anti-SNX6 Antibody
Antibody SKU:	CAB10039
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human SNX6 (NP_067072.3).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	HepG2, DU145, BT-474, Mouse kidney, Mouse lung, Mouse thymus, Mouse pancreas, Rat kidney

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human SNX6 (NP_067072.3).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MTKE EFTK MKQE LEAE YLAI FKKT VAMH EVFL CRVA AHPI LRRD LNFH VFLE YNQD LSVR GKNK KEKL EDFF KNMV KSAD GVIV SGVK DVDD FFEH ERTF LLEY HNRV KDAS AKSD RMTR SHKS AADD YNRI GSSL YALG TQDS TDIC KFFL KVSE LFDK TRKI EARV SADE DLKL SDLL KYYL RESQ AAKD LLYR RSRS LVDY ENAN KALD KARA KNKD VLQA ETSQ QLCC QKFE KISE SAKQ ELID FKTR RVAA FRKN LVEL AELE LKHA KGNL QLLQ NCLA VLNG DT
Gene ID:	58533
Uniprot:	Q9UNH7
Cellular Location:	Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Early endosome, Early endosome membrane, Nucleus, Peripheral membrane protein
Calculated MW:	33kDa/46kDa
Observed MW:	46kDa

Synonyms:

SNX6, MSTP010, TFAF2

Background:

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms.

UniProt Protein Function:	SNX6: May be involved in several stages of intracellular trafficking. Promotes lysosomal degradation of CDKN1B. Plays a role in retrograde protein transport from endosomes to the trans-Golgi network. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. May contribute to transcription regulation. Belongs to the sorting nexin family.
UniProt Protein Details:	Protein type:Vesicle Chromosomal Location of Human Ortholog: 14q13.1 Cellular Component: cytoplasm; early endosome membrane; extrinsic to membrane; retromer complex Molecular Function:phosphoinositide binding; protein binding; protein homodimerization activity Biological Process: endocytosis; intracellular protein transport; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway; retrograde transport, endosome to Golgi; vesicle organization and biogenesis
NCBI Summary:	This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9UNH7
NCBI GenInfo Identifier:	10720285
NCBI Gene ID:	58533
NCBI Accession:	Q9UNH7.1
UniProt Secondary Accession:	Q9UNH7,Q9Y449, C0H5W9,
UniProt Related Accession:	Q9UNH7
Molecular Weight:	33,570 Da
NCBI Full Name:	Sorting nexin-6
NCBI Synonym Full Names:	sorting nexin 6
NCBI Official Symbol:	SNX6
NCBI Official Synonym Symbols:	TFAF2; MSTP010
NCBI Protein Information:	sorting nexin-6
UniProt Protein Name:	Sorting nexin-6
UniProt Synonym Protein Names:	TRAF4-associated factor 2
Protein Family:	Sorting nexin
UniProt Gene Name:	SNX6
UniProt Entry Name:	SNX6_HUMAN

Western blot analysis of extracts of various cell lines, using SNX6 antibody (CAB10039) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.

Antibodies

SNX6 Antibody (PACO12386)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)