Cell Biology Antibodies 3

Anti-SNX5 Antibody (CAB13160)

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SKU:
CAB13160
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-SNX5 Antibody
Antibody SKU:CAB13160
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 145-404 of human SNX5 (NP_055241.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, U-87MG, Mouse thymus, Mouse brain, Mouse kidney, Rat thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 145-404 of human SNX5 (NP_055241.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VFLQ RLSS HPVL SKDR NFHV FLEY DQDL SVRR KNTK EMFG GFFK SVVK SADE VLFT GVKE VDDF FEQE KNFL INYY NRIK DSCV KADK MTRS HKNV ADDY IHTA ACLH SLAL EEPT VIKK YLLK VAEL FEKL RKVE GRVS SDED LKLT ELLR YYML NIEA AKDL LYRR TKAL IDYE NSNK ALDK ARLK SKDV KLAE AHQQ ECCQ KFEQ LSES AKEE LINF KRKR VAAF RKNL IEMS ELEI KHAR NNVS LLQS CIDL FKNN
Gene ID:27131
Uniprot:Q9Y5X3
Cellular Location:Cell membrane, Cell projection, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle membrane, Early endosome, Early endosome membrane, Endosome, Peripheral membrane protein, phagocytic cup, ruffle
Calculated MW:13kDa/46kDa
Observed MW:47kDa
Synonyms:SNX5
Background:This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, the phosphoinositide-signaling pathway, and macropinocytosis. This gene may play a role in the tumorigenesis of papillary thyroid carcinoma. Alternative splicing results in multiple transcript variants encoding different isoforms.
UniProt Protein Function:SNX5: May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation. Belongs to the sorting nexin family.
UniProt Protein Details:

Protein type:Vesicle

Chromosomal Location of Human Ortholog: 20p11

Cellular Component: ruffle; extrinsic to internal side of plasma membrane; cytoplasmic vesicle membrane; early endosome membrane; retromer complex; phagocytic cup

Molecular Function:protein binding; phosphoinositide binding

Biological Process: pinocytosis; intracellular protein transport; vesicle organization and biogenesis; retrograde transport, endosome to Golgi

NCBI Summary:This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, the phosphoinositide-signaling pathway, and macropinocytosis. This gene may play a role in the tumorigenesis of papillary thyroid carcinoma. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
UniProt Code:Q9Y5X3
NCBI GenInfo Identifier:10720289
NCBI Gene ID:27131
NCBI Accession:Q9Y5X3.1
UniProt Secondary Accession:Q9Y5X3,Q52LC4, Q7KZN0, Q9BWP0, B7ZKN3, D3DW26,
UniProt Related Accession:Q9Y5X3
Molecular Weight:404
NCBI Full Name:Sorting nexin-5
NCBI Synonym Full Names:sorting nexin 5
NCBI Official Symbol:SNX5  
NCBI Protein Information:sorting nexin-5
UniProt Protein Name:Sorting nexin-5
Protein Family:Sorting nexin
UniProt Gene Name:SNX5  
UniProt Entry Name:SNX5_HUMAN
Anti-SNX5 Antibody (CAB13160)Western blot analysis of extracts of various cell lines, using SNX5 antibody (CAB13160) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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