Cell Biology Antibodies 11
Anti-SNX3 Antibody (CAB7502)
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- SKU:
- CAB7502
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SNX3 Antibody |
| Antibody SKU: | CAB7502 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-162 of human SNX3 (NP_003786.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HL-60, THP-1, SKOV3, Mouse kidney, Mouse spleen, Mouse brain, Rat kidney, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-162 of human SNX3 (NP_003786.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAET VADT RRLI TKPQ NLND AYGP PSNF LEID VSNP QTVG VGRG RFTT YEIR VKTN LPIF KLKE STVR RRYS DFEW LRSE LERE SKVV VPPL PGKA FLRQ LPFR GDDG IFDD NFIE ERKQ GLEQ FINK VAGH PLAQ NERC LHMF LQDE IIDK SYTP SKIR HA |
| Gene ID: | 8724 |
| Uniprot: | O60493 |
| Cellular Location: | Cytoplasmic vesicle, Early endosome, phagosome |
| Calculated MW: | 13kDa/14kDa/16kDa/18kDa |
| Observed MW: | 19kDa |
| Synonyms: | SNX3, Grd19, MCOPS8, SDP3 |
| Background: | This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking. A pseudogene of this gene is present on the sex chromosomes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| UniProt Protein Function: | SNX3: Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G. Not involved in EGFR degradation. A chromosomal aberration involving SNX3 may be a cause of microphthalmia syndromic type 8 (MCOPS8). Translocation t(6;13)(q21;q12). Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS8 is a very rare congenital syndrome characterized by microcephaly, microphthalmia, ectrodactyly of the lower limbs and prognathism. Intellectual deficit has been reported. Belongs to the sorting nexin family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 6q21 Cellular Component: clathrin-coated vesicle; cytoplasm; cytosol; early endosome; early endosome membrane; endosome membrane; extrinsic to membrane; retromer complex Molecular Function:phosphatidylinositol 3-phosphate binding; phosphatidylinositol-5-phosphate binding; protein binding; protein phosphatase binding Biological Process: membrane invagination; negative regulation of phagocytosis; negative regulation of protein catabolic process; negative regulation of protein transport; negative regulation of virion penetration into host cell; protein to membrane docking; regulation of Wnt receptor signaling pathway; response to bacterium; Wnt receptor signaling pathway Disease: Microphthalmia, Syndromic 8 |
| NCBI Summary: | This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking. A pseudogene of this gene is present on the sex chromosomes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014] |
| UniProt Code: | O60493 |
| NCBI GenInfo Identifier: | 12643620 |
| NCBI Gene ID: | 8724 |
| NCBI Accession: | O60493.3 |
| UniProt Secondary Accession: | O60493,O60718, Q4TT29, Q4TT31, Q5JXJ7, Q5JXJ8, Q96AP9 Q9C0J5, Q9NU45, A8K0B1, E1P5E4, E1P5E5, |
| UniProt Related Accession: | O60493 |
| Molecular Weight: | 16,316 Da |
| NCBI Full Name: | Sorting nexin-3 |
| NCBI Synonym Full Names: | sorting nexin 3 |
| NCBI Official Symbol: | SNX3 |
| NCBI Official Synonym Symbols: | SDP3; Grd19; MCOPS8 |
| NCBI Protein Information: | sorting nexin-3 |
| UniProt Protein Name: | Sorting nexin-3 |
| UniProt Synonym Protein Names: | Protein SDP3 |
| Protein Family: | Sorting nexin |
| UniProt Gene Name: | SNX3 |
| UniProt Entry Name: | SNX3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SNX3 antibody (CAB7502) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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