Cell Biology Antibodies 18
Anti-SNX2 Antibody (CAB18383)
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- SKU:
- CAB18383
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SNX2 Antibody |
| Antibody SKU: | CAB18383 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human SNX2. |
| Application: | IHC |
| Recommended Dilution: | IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant protein of human SNX2. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6643 |
| Uniprot: | O60749 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | TRG-9, SNX2 |
| Background: |
| UniProt Protein Function: | SNX2: May be involved in several stages of intracellular trafficking. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Belongs to the sorting nexin family. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 5q23 Cellular Component: cytoplasm; endosome membrane; extrinsic to membrane; membrane; protein complex; retromer complex Molecular Function:epidermal growth factor receptor binding; insulin receptor binding; phosphoinositide binding; protein binding; protein heterodimerization activity; protein homodimerization activity Biological Process: endocytosis; protein oligomerization; retrograde transport, endosome to Golgi; vesicle organization and biogenesis |
| NCBI Summary: | This gene belongs to the sorting nexin family whose members contain the phosphoinositide-binding phox (PX) domain. The encoded protein is a component of the retromer complex which plays a role in protein sorting in the endocytic pathway. This protein may form oligomeric complexes with other family members. Alternate splicing results in multiple transcript variants of this gene. Pseudogenes associated with this gene are located on chromosomes 1 and 7. [provided by RefSeq, May 2013] |
| UniProt Code: | O60749 |
| NCBI GenInfo Identifier: | 110826413 |
| NCBI Gene ID: | 6643 |
| NCBI Accession: | O60749.2 |
| UniProt Secondary Accession: | O60749,O43650, P82862, Q53XK8, Q597H6, Q9BTS8, B3KN44 B4DEK4, B7Z408, |
| UniProt Related Accession: | O60749 |
| Molecular Weight: | 46,098 Da |
| NCBI Full Name: | Sorting nexin-2 |
| NCBI Synonym Full Names: | sorting nexin 2 |
| NCBI Official Symbol: | SNX2 |
| NCBI Official Synonym Symbols: | TRG-9 |
| NCBI Protein Information: | sorting nexin-2 |
| UniProt Protein Name: | Sorting nexin-2 |
| UniProt Synonym Protein Names: | Transformation-related gene 9 protein; TRG-9 |
| Protein Family: | Sorting nexin |
| UniProt Gene Name: | SNX2 |
| UniProt Entry Name: | SNX2_HUMAN |
