Cell Biology Antibodies 9
Anti-SNX19 Antibody (CAB5229)
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- SKU:
- CAB5229
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SNX19 Antibody |
| Antibody SKU: | CAB5229 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 550-750 of human SNX19 (NP_055573.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, Mouse testis, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 550-750 of human SNX19 (NP_055573.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HPYT LYTV KYET ALDG ENSS GLQQ LAYH TVNR RYRE FLNL QTRL EEKP DLRK FIKN VKGP KKLF PDLP FGNM DSDR VEAR KSLL ESFL KQLC AIPE IANS EEVQ EFLA LNTD ARIA FVKK PFMV SRID KMVV SAIV DTLK TAFP RSEP QSPT EELS EAET ESKP QTEG KKAS KSRL RFSS SKIS PALS VTEA QDKI LYCL Q |
| Gene ID: | 399979 |
| Uniprot: | Q92543 |
| Cellular Location: | Cytoplasmic side, Cytoplasmic vesicle membrane, Early endosome membrane, Peripheral membrane protein |
| Calculated MW: | 87kDa/108kDa |
| Observed MW: | 108kDa |
| Synonyms: | SNX19, CHET8 |
| Background: | Islet antigen-2 (IA-2) is an autoantigen in type 1 diabetes and plays a role in insulin secretion. IA-2 is found in dense-core secretory vesicles and interacts with the product of this gene, a sorting nexin. In mouse pancreatic beta-cells, the encoded protein influenced insulin secretion by stabilizing the number of dense-core secretory vesicles. |
| UniProt Protein Function: | SNX19: May be involved in several stages of intracellular trafficking. Belongs to the sorting nexin family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 11q25 Cellular Component: cytoplasmic vesicle membrane; cytoplasm Molecular Function:protein binding; phosphoinositide binding Biological Process: insulin secretion; chondrocyte differentiation |
| UniProt Code: | Q92543 |
| NCBI GenInfo Identifier: | 296452910 |
| NCBI Gene ID: | 399979 |
| NCBI Accession: | Q92543.2 |
| UniProt Secondary Accession: | Q92543,Q8IV55, E9PKB9, |
| UniProt Related Accession: | Q92543 |
| Molecular Weight: | 992 |
| NCBI Full Name: | Sorting nexin-19 |
| NCBI Synonym Full Names: | sorting nexin 19 |
| NCBI Official Symbol: | SNX19 |
| NCBI Official Synonym Symbols: | CHET8 |
| NCBI Protein Information: | sorting nexin-19 |
| UniProt Protein Name: | Sorting nexin-19 |
| Protein Family: | Sorting nexin |
| UniProt Gene Name: | SNX19 |
| UniProt Entry Name: | SNX19_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SNX19 antibody (CAB5229) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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