Cell Cycle Antibodies 1

Anti-SNX18 Antibody (CAB10337)

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SKU:
CAB10337
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Cycle

Description

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Antibody Name:Anti-SNX18 Antibody
Antibody SKU:CAB10337
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 445-624 of human SNX18 (NP_001096045.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:LO2, SKOV3, A-549, HeLa, Mouse kidney, Mouse pancreas, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 445-624 of human SNX18 (NP_001096045.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LNHT ANEF ARKQ VTGF KKEY QKVG QSFR GLSQ AFEL DQQA FSVG LNQA IAFT GDAY DAIG ELFA EQPR QDLD PVMD LLAL YQGH LANF PDII HVQK GALT KVKE SRRH VEEG KMEV QKAD GIQD RCNT ISFA TLAE IHHF HQIR VRDF KSQM QHFL QQQI IFFQ KVTQ KLEE ALHK YDSV
Gene ID:112574
Uniprot:Q96RF0
Cellular Location:Cell membrane, Cytoplasmic side, Cytoplasmic vesicle membrane, Endomembrane system, Endosome membrane, Peripheral membrane protein
Calculated MW:64kDa/68kDa/69kDa
Observed MW:75kDa
Synonyms:SNX18, SH3PX2, SH3PXD3B, SNAG1
Background:This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:SNX18: May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane. Belongs to the sorting nexin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Vesicle; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: clathrin-coated vesicle; cytoplasmic membrane-bound vesicle; endosome; extrinsic to internal side of plasma membrane; intracellular membrane-bound organelle; nucleoplasm

Molecular Function:phosphatidylinositol-4,5-bisphosphate binding; protein binding

Biological Process: cytokinesis after mitosis; endocytosis; endosome transport; positive regulation of GTPase activity; vesicle organization and biogenesis

NCBI Summary:This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q96RF0
NCBI GenInfo Identifier:215273942
NCBI Gene ID:112574
NCBI Accession:Q96RF0.2
UniProt Secondary Accession:Q96RF0,Q05BB3, Q0VG02, B4E2B3, H7BXX3,
UniProt Related Accession:Q96RF0
Molecular Weight:64,752 Da
NCBI Full Name:Sorting nexin-18
NCBI Synonym Full Names:sorting nexin 18
NCBI Official Symbol:SNX18  
NCBI Official Synonym Symbols:SNAG1; SH3PX2; SH3PXD3B  
NCBI Protein Information:sorting nexin-18
UniProt Protein Name:Sorting nexin-18
UniProt Synonym Protein Names:SH3 and PX domain-containing protein 3B; Sorting nexin-associated Golgi protein 1
Protein Family:Sorting nexin
UniProt Gene Name:SNX18  
UniProt Entry Name:SNX18_HUMAN
Anti-SNX18 Antibody (CAB10337)Western blot analysis of extracts of various cell lines, using SNX18 antibody (CAB10337) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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