Cell Biology Antibodies 1
Anti-SNX17 Antibody (CAB10274)
(No reviews yet)
Write a Review
- SKU:
- CAB10274
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SNX17 Antibody |
| Antibody SKU: | CAB10274 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human SNX17 (NP_055563.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | A-549 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human SNX17 (NP_055563.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MHFS IPET ESRS GDSG GSAY VAYN IHVN GVLH CRVR YSQL LGLH EQLR KEYG ANVL PAFP PKKL FSLT PAEV EQRR EQLE KYMQ AVRQ DPLL GSSE TFNS FLRR AQQE TQQV PTEE VSLE VLLS NGQK VLVN VLTS DQTE DVLE AVAA KLDL PDDL IGYF SLFL VREK EDGA FSFV RKLQ EFEL PYVS VTSL RSQE YKIV LRKS YWDS AYDD DVME NRVG LNLL YAQT VSDI ERGW ILVT KEQH RQLK SLQE KVSK KEFL RLAQ TLRH YG |
| Gene ID: | 9784 |
| Uniprot: | Q15036 |
| Cellular Location: | Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle membrane, Early endosome, Peripheral membrane protein |
| Calculated MW: | 49kDa/52kDa |
| Observed MW: | 45kDa |
| Synonyms: | SNX17 |
| Background: | This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | SNX17: May be involved in several stages of intracellular protein trafficking. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)). Belongs to the sorting nexin family. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 2p23.3 Cellular Component: cytoplasm; cytoplasmic membrane-bound vesicle; cytosol; early endosome; endosome; endosome membrane; Golgi apparatus; intracellular membrane-bound organelle; protein complex Molecular Function:low-density lipoprotein receptor binding; phosphoinositide binding; protein binding; protein C-terminus binding Biological Process: cholesterol catabolic process; intracellular protein transport |
| NCBI Summary: | This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012] |
| UniProt Code: | Q15036 |
| NCBI GenInfo Identifier: | 3123050 |
| NCBI Gene ID: | 9784 |
| NCBI Accession: | Q15036.1 |
| UniProt Secondary Accession: | Q15036,Q53HN7, Q6IAS3, B4DQM7, |
| UniProt Related Accession: | Q15036 |
| Molecular Weight: | 49,999 Da |
| NCBI Full Name: | Sorting nexin-17 |
| NCBI Synonym Full Names: | sorting nexin 17 |
| NCBI Official Symbol: | SNX17 |
| NCBI Protein Information: | sorting nexin-17 |
| UniProt Protein Name: | Sorting nexin-17 |
| Protein Family: | Sorting nexin |
| UniProt Gene Name: | SNX17 |
| UniProt Entry Name: | SNX17_HUMAN |
 | Western blot analysis of extracts of A-549 cells, using SNX17 antibody (CAB10274) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
View AllClose
Related Products
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
Human Anti-DSG3 antibody(anti-Desmoglein-3 antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक