Signal Transduction Antibodies 1
Anti-SNUPN Antibody (CAB13736)
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- SKU:
- CAB13736
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-SNUPN Antibody |
| Antibody SKU: | CAB13736 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-360 of human SNUPN (NP_005692.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, HeLa, 293T, Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-360 of human SNUPN (NP_005692.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEEL SQAL ASSF SVSQ DLNS TAAP HPRL SQYK SKYS SLEQ SERR RRLL ELQK SKRL DYVN HARR LAED DWTG MESE EENK KDDE EMDI DTVK KLPK HYAN QLML SEWL IDVP SDLG QEWI VVVC PVGK RALI VASR GSTS AYTK SGYC VNRF SSLL PGGN RRNS TAKD YTIL DCIY NEVN QTYY VLDV MCWR GHPF YDCQ TDFR FYWM HSKL PEEE GLGE KTKL NPFK FVGL KNFP CTPE SLCD VLSM DFPF EVDG LLFY HKQT HYSP GSTP LVGW LRPY MVSD VLGV AVPA GPLT TKPD YAGH QLQQ IMEH KKSQ KEGM KEKL THKA SENG HYEL EHLS TPKL KGSS HSPD HPGC LMEN |
| Gene ID: | 10073 |
| Uniprot: | O95149 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 41kDa |
| Observed MW: | 41kDa |
| Synonyms: | SNUPN, KPNBL, RNUT1, Snurportin1 |
| Background: | The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2, 2, 7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. |
| UniProt Protein Function: | RNUT1: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. Belongs to the snurportin family. |
| UniProt Protein Details: | Protein type:RNA-binding; Nuclear import Chromosomal Location of Human Ortholog: 15q24.2 Cellular Component: cytosol; nuclear pore Molecular Function:RNA cap binding Biological Process: nuclear import; spliceosomal snRNP biogenesis |
| NCBI Summary: | The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95149 |
| NCBI GenInfo Identifier: | 74735576 |
| NCBI Gene ID: | 10073 |
| NCBI Accession: | O95149.1 |
| UniProt Secondary Accession: | O95149,A6NE34, A8K0B0, D3DW76, |
| UniProt Related Accession: | O95149 |
| Molecular Weight: | 41,143 Da |
| NCBI Full Name: | Snurportin-1 |
| NCBI Synonym Full Names: | snurportin 1 |
| NCBI Official Symbol: | SNUPN |
| NCBI Official Synonym Symbols: | KPNBL; RNUT1; Snurportin1 |
| NCBI Protein Information: | snurportin-1 |
| UniProt Protein Name: | Snurportin-1 |
| UniProt Synonym Protein Names: | RNA U transporter 1 |
| UniProt Gene Name: | SNUPN |
| UniProt Entry Name: | SPN1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SNUPN antibody (CAB13736) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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