Cell Biology Antibodies 18

Anti-SNTB2 Antibody (CAB18384)

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SKU:
CAB18384
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-SNTB2 Antibody
Antibody SKU:CAB18384
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant protein of human SNTB2.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:
Immunogen:Recombinant protein of human SNTB2.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6645
Uniprot:Q13425
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:D16S2531E, EST25263, SNT2B2, SNT3, SNTL, SNTB2
Background:
UniProt Protein Function:SNTB2: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN. Monomer and homodimer (Probable). Interacts with the other members of the syntrophin family: SNTA1 and SNTB1; and with the sodium channel proteins SCN4A and SCN5A. Interacts with SAST, MAST205, microtubules and microtubule-associated proteins. Interacts with the dystrophin protein DMD and related proteins DTNA and UTRN, and with the neuroregulin receptor ERBB4. Interacts with PTPRN when phosphorylated, protecting PTPRN from protein cleavage by CAPN1. Dephosphorylation upon insulin stimulation disrupts the interaction with PTPRN and results in the cleavage of PTPRN. Ubiquitous. Isoform 1 is the predominant isoform. Weak level of isoform 2 is present in all tested tissues, except in liver and heart where it is highly expressed. Belongs to the syntrophin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Extracellular matrix; Dystrophin complex; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: cytoplasm; dystrophin-associated glycoprotein complex; focal adhesion; membrane; protein complex

Molecular Function:protein binding

NCBI Summary:Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes. [provided by RefSeq, Jul 2008]
UniProt Code:Q13425
NCBI GenInfo Identifier:23822158
NCBI Gene ID:6645
NCBI Accession:Q13425.1
UniProt Secondary Accession:Q13425,Q9BY09,
UniProt Related Accession:Q13425
Molecular Weight:27,677 Da
NCBI Full Name:Beta-2-syntrophin
NCBI Synonym Full Names:syntrophin beta 2
NCBI Official Symbol:SNTB2  
NCBI Official Synonym Symbols:SNT3; SNTL; SNT2B2; EST25263; D16S2531E  
NCBI Protein Information:beta-2-syntrophin
UniProt Protein Name:Beta-2-syntrophin
UniProt Synonym Protein Names:59 kDa dystrophin-associated protein A1 basic component 2; Syntrophin-3; SNT3; Syntrophin-like; SNTL
Protein Family:Beta-2-syntrophin
UniProt Gene Name:SNTB2  
UniProt Entry Name:SNTB2_HUMAN
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