Name: Anti-SNRPN Antibody (CAB15726)
Brand: Cell Biology Antibodies 6
SKU: CAB15726
Availability: OutOfStock

Antibody Name:	Anti-SNRPN Antibody
Antibody SKU:	CAB15726
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SNRPN (NP_003088.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	293T, HT-29, HeLa, Mouse brain, Rat brain

Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SNRPN (NP_003088.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MTVG KSSK MLQH IDYR MRCI LQDG RIFI GTFK AFDK HMNL ILCD CDEF RKIK PKNA KQPE REEK RVLG LVLL RGEN LVSM TVEG PPPK DTGI ARVP LAGA
Gene ID:	6638
Uniprot:	P63162
Cellular Location:	Nucleus
Calculated MW:	24kDa/25kDa
Observed MW:	20kDa

Synonyms:

SNRPN, HCERN3, PWCR, RT-LI, SM-D, SMN, SNRNP-N, SNURF-SNRPN, sm-N, PWS

Background:

The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure.

UniProt Protein Function:	snRNP N: May be involved in tissue-specific alternative RNA processing events. Belongs to the snRNP SmB/SmN family.
UniProt Protein Details:	Protein type:RNA-binding Chromosomal Location of Human Ortholog: 15q11.2 Cellular Component: small nuclear ribonucleoprotein complex; spliceosome; snRNP U2; snRNP U1 Molecular Function:protein binding; RNA binding Biological Process: RNA splicing; response to hormone stimulus Disease: Prader-willi Syndrome; Autism
NCBI Summary:	The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure. [provided by RefSeq, Jul 2008]
UniProt Code:	P63162
NCBI GenInfo Identifier:	52783794
NCBI Gene ID:	6638
NCBI Accession:	P63162.1
UniProt Secondary Accession:	P63162,P14648, P17135, Q0D2Q5, B3KVR1,
UniProt Related Accession:	P63162
Molecular Weight:	25,076 Da
NCBI Full Name:	Small nuclear ribonucleoprotein-associated protein N
NCBI Synonym Full Names:	small nuclear ribonucleoprotein polypeptide N
NCBI Official Symbol:	SNRPN
NCBI Official Synonym Symbols:	SMN; PWCR; SM-D; sm-N; RT-LI; HCERN3; SNRNP-N; SNURF-SNRPN
NCBI Protein Information:	small nuclear ribonucleoprotein-associated protein N; SM protein N; sm protein D; tissue-specific splicing protein
UniProt Protein Name:	Small nuclear ribonucleoprotein-associated protein N
UniProt Synonym Protein Names:	Sm protein D; Sm-D; Sm protein N; Sm-N; SmN; Tissue-specific-splicing protein
Protein Family:	SNRPN upstream reading frame protein
UniProt Gene Name:	SNRPN
UniProt Entry Name:	RSMN_HUMAN

Western blot analysis of extracts of various cell lines, using SNRPN antibody (CAB15726) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.

Antibodies

SNRPN Antibody (PACO03234)

SNRPN Antibody (PACO12374)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)