Epigenetics & Nuclear Signaling Antibodies 3
Anti-SNRPE Antibody (CAB5488)
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- SKU:
- CAB5488
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-SNRPE Antibody |
| Antibody SKU: | CAB5488 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-92 of human SNRPE (NP_003085.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | K-562, HepG2, U-937 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-92 of human SNRPE (NP_003085.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAYR GQGQ KVQK VMVQ PINL IFRY LQNR SRIQ VWLY EQVN MRIE GCII GFDE YMNL VLDD AEEI HSKT KSRK QLGR IMLK GDNI TLLQ SVSN |
| Gene ID: | 6635 |
| Uniprot: | P62304 |
| Cellular Location: | Cytoplasm, Nucleus, cytosol |
| Calculated MW: | 10kDa |
| Observed MW: | 11kDa |
| Synonyms: | SNRPE, HYPT11, SME, Sm-E, snRNP-E |
| Background: | The protein encoded by this gene is a core component of U small nuclear ribonucleoproteins, which are key components of the pre-mRNA processing spliceosome. The encoded protein plays a role in the 3' end processing of histone transcripts. This protein is one of the targets in the autoimmune disease systemic lupus erythematosus, and mutations in this gene have been associated with hypotrichosis. Several pseudogenes of this gene have been identified. |
| UniProt Protein Function: | snRNP E: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Associated with snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. |
| UniProt Protein Details: | Protein type:Spliceosome; RNA splicing Chromosomal Location of Human Ortholog: 1q32 Cellular Component: nucleoplasm; small nuclear ribonucleoprotein complex; spliceosome; U4/U6 x U5 tri-snRNP complex; snRNP U5; snRNP U2; snRNP U1; nucleus; cytosol; U12-dependent spliceosome Molecular Function:protein binding; RNA binding Biological Process: transcription from RNA polymerase II promoter; nuclear mRNA splicing, via spliceosome; spliceosomal snRNP biogenesis; RNA splicing; histone mRNA metabolic process; spliceosome assembly; gene expression; mRNA 3'-end processing; termination of RNA polymerase II transcription; hair cycle Disease: Hypotrichosis 11 |
| UniProt Code: | P62304 |
| NCBI GenInfo Identifier: | 61237380 |
| NCBI Gene ID: | 6635 |
| NCBI Accession: | P62304.1 |
| UniProt Secondary Accession: | P62304,P08578, Q15498, Q5BKT2, B2R5B9, |
| UniProt Related Accession: | P62304 |
| Molecular Weight: | 92 |
| NCBI Full Name: | Small nuclear ribonucleoprotein E |
| NCBI Synonym Full Names: | small nuclear ribonucleoprotein polypeptide E |
| NCBI Official Symbol: | SNRPE |
| NCBI Official Synonym Symbols: | SME; Sm-E; B-raf; HYPT11 |
| NCBI Protein Information: | small nuclear ribonucleoprotein E; snRNP-E; sm protein E |
| UniProt Protein Name: | Small nuclear ribonucleoprotein E |
| UniProt Synonym Protein Names: | Sm protein E; Sm-E; SmE |
| Protein Family: | Small nuclear ribonucleoprotein |
| UniProt Gene Name: | SNRPE |
| UniProt Entry Name: | RUXE_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SNRPE antibody (CAB5488) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded rat ovary using SNRPE Rabbit pAb (CAB5488) at dilution of 1:50 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human thyroid cancer using SNRPE Rabbit pAb (CAB5488) at dilution of 1:50 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using SNRPE antibody (CAB5488). Blue: DAPI for nuclear staining. |
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