Epigenetics & Nuclear Signaling Antibodies 2

Anti-SNRPD3 Antibody (CAB16070)

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SKU:
CAB16070
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-SNRPD3 Antibody
Antibody SKU:CAB16070
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 8-121 of human SNRPD3 (NP_001265585).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, DU145, Mouse brain, Mouse liver, Rat pancreas
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 8-121 of human SNRPD3 (NP_001265585).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KVLH EAEG HIVT CETN TGEV YRGK LIEA EDNM NCQM SNIT VTYR DGRV AQLE QVYI RGSK IRFL ILPD MLKN APML KSMK NKNQ GSGA GRGK AAIL KAQV AARG RGRG MGRG NI
Gene ID:6634
Uniprot:P62318
Cellular Location:Cytoplasm, Nucleus, cytosol
Calculated MW:13kDa
Observed MW:14kDa
Synonyms:SNRPD3, SMD3, Sm-D3
Background:This gene encodes a core component of the spliceosome, which is a nuclear ribonucleoprotein complex that functions in pre-mRNA splicing. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:snRNP D3: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner. Belongs to the snRNP core protein family.
UniProt Protein Details:

Protein type:RNA splicing; Spliceosome; RNA-binding

Chromosomal Location of Human Ortholog: 22q11.23

Cellular Component: cytoplasm; cytosol; nucleoplasm; small nuclear ribonucleoprotein complex; snRNP U1; snRNP U2; snRNP U5; spliceosome; telomerase holoenzyme complex; U12-dependent spliceosome

Molecular Function:enzyme binding; protein binding

Biological Process: histone mRNA metabolic process; nuclear import; nuclear mRNA splicing, via spliceosome; protein amino acid methylation; RNA splicing; spliceosomal snRNP biogenesis; spliceosome assembly; termination of RNA polymerase II transcription

NCBI Summary:This gene encodes a core component of the spliceosome, which is a nuclear ribonucleoprotein complex that functions in pre-mRNA splicing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Code:P62318
NCBI GenInfo Identifier:51338667
NCBI Gene ID:6634
NCBI Accession:P62318.1
UniProt Secondary Accession:P62318,P43331, B4DJP7, B5BU13,
UniProt Related Accession:P62318
Molecular Weight:13,292 Da
NCBI Full Name:Small nuclear ribonucleoprotein Sm D3
NCBI Synonym Full Names:small nuclear ribonucleoprotein D3 polypeptide
NCBI Official Symbol:SNRPD3  
NCBI Official Synonym Symbols:SMD3; Sm-D3  
NCBI Protein Information:small nuclear ribonucleoprotein Sm D3
UniProt Protein Name:Small nuclear ribonucleoprotein Sm D3
UniProt Synonym Protein Names:snRNP core protein D3
UniProt Gene Name:SNRPD3  
UniProt Entry Name:SMD3_HUMAN
Anti-SNRPD3 Antibody (CAB16070)Western blot analysis of extracts of various cell lines, using SNRPD3 antibody (CAB16070) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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