Epigenetics & Nuclear Signaling Antibodies 4

Anti-SNRPB2 Antibody (CAB8908)

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SKU:
CAB8908
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-SNRPB2 Antibody
Antibody SKU:CAB8908
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human SNRPB2 (NP_003083.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, U-87MG, HT-1080, LO2, 293T, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human SNRPB2 (NP_003083.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDIR PNHT IYIN NMND KIKK EELK RSLY ALFS QFGH VVDI VALK TMKM RGQA FVIF KELG SSTN ALRQ LQGF PFYG KPMR IQYA KTDS DIIS KMRG TFAD KEKK KEKK KAKT VEQT ATTT NKKP GQGT PNSA NTQG NSTP NPQV PDYP PN
Gene ID:6629
Uniprot:P08579
Cellular Location:Nucleus
Calculated MW:25kDa
Observed MW:30kDa
Synonyms:SNRPB2, Msl1, U2B
Background:The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene.
UniProt Protein Function:snRNP B2: a small nuclear ribonucleoprotein. Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA only in presence of the A' protein.
UniProt Protein Details:

Protein type:RNA processing; RNA splicing; Spliceosome; RNA-binding

Chromosomal Location of Human Ortholog: 20p12.1

Cellular Component: nucleolus; nucleoplasm; snRNP U2; spliceosome

Molecular Function:protein binding

Biological Process: nuclear mRNA splicing, via spliceosome; positive regulation of defense response to virus by host

NCBI Summary:The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P08579
NCBI GenInfo Identifier:134095
NCBI Gene ID:6629
NCBI Accession:P08579.1
UniProt Secondary Accession:P08579,Q9UJD4, B2R7J3, D3DW21,
UniProt Related Accession:P08579
Molecular Weight:25,486 Da
NCBI Full Name:U2 small nuclear ribonucleoprotein B''
NCBI Synonym Full Names:small nuclear ribonucleoprotein polypeptide B2
NCBI Official Symbol:SNRPB2  
NCBI Official Synonym Symbols:Msl1; U2B''  
NCBI Protein Information:U2 small nuclear ribonucleoprotein B''
UniProt Protein Name:U2 small nuclear ribonucleoprotein B''
UniProt Gene Name:SNRPB2  
UniProt Entry Name:RU2B_HUMAN
Anti-SNRPB2 Polyclonal Antibody (CAB8908)Western blot analysis of extracts of various cell lines, using SNRPB2 antibody (CAB8908) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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