Anti-SND1 Antibody (CAB5874)

Name: Anti-SND1 Antibody (CAB5874)[KO Validated]
Brand: KO Validated Antibodies 1
SKU: CAB5874
Availability: OutOfStock

Antibody Name:	Anti-SND1 Antibody [KO Validated]
Antibody SKU:	CAB5874
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC IF IP
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 26-285 of human SND1 (NP_055205.2).

Application:	WB IHC IF IP
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	HeLa, Jurkat, HL-60, MCF7, 293T, Mouse liver, Rat liver

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 26-285 of human SND1 (NP_055205.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MVLS GCAI IVRG QPRG GPPP ERQI NLSN IRAG NLAR RAAA TQPD AKDT PDEP WAFP AREF LRKK LIGK EVCF TIEN KTPQ GREY GMIY LGKD TNGE NIAE SLVA EGLA TRRE GMRA NNPE QNRL SECE EQAK AAKK GMWS EGNG SHTI RDLK YTIE NPRH FVDS HHQK PVNA IIEH VRDG SVVR ALLL PDYY LVTV MLSG IKCP TFRR EADG SETP EPFA AEAK FFTE SRLL QRDV QIIL ESCH NQNI LGTI LHPN GNIT
Gene ID:	27044
Uniprot:	Q7KZF4
Cellular Location:	Cytoplasm, Melanosome, Nucleus
Calculated MW:	101kDa
Observed MW:	120kDa

Synonyms:

SND1, TDRD11, Tudor-SN, p100

Background:

This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. This protein is also thought to be essential for normal cell growth. A similar protein in mammals and other organisms is a component of the RNA-induced silencing complex (RISC). [provided by RefSeq, Jul 2016]

UniProt Protein Function:	SND1: a transcriptional coactivator for STAT6. May function as a bridging factor between STAT6 and the basal transcription machinery.
UniProt Protein Details:	Protein type:Transcription, coactivator/corepressor; RNA-binding Chromosomal Location of Human Ortholog: 7q31.3 Cellular Component: membrane; mitochondrion; cytoplasm; melanosome; nucleus Molecular Function:protein binding; nuclease activity; transcription cofactor activity Biological Process: osteoblast differentiation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; viral reproduction; RNA-mediated gene silencing
UniProt Code:	Q7KZF4
NCBI GenInfo Identifier:	60415926
NCBI Gene ID:	27044
NCBI Accession:	Q7KZF4.1
UniProt Secondary Accession:	Q7KZF4,Q13122, Q96AG0,
UniProt Related Accession:	Q7KZF4
Molecular Weight:	910
NCBI Full Name:	Staphylococcal nuclease domain-containing protein 1
NCBI Synonym Full Names:	staphylococcal nuclease and tudor domain containing 1
NCBI Official Symbol:	SND1
NCBI Official Synonym Symbols:	p100; TDRD11
NCBI Protein Information:	staphylococcal nuclease domain-containing protein 1; Tudor-SN; SND1-BRAF fusion; p100 co-activator; 100 kDa coactivator; EBNA2 coactivator p100; p100 EBNA2 co-activator; EBNA-2 co-activator (100kD); tudor domain-containing protein 11; staphylococcal nuclease domain containing 1
UniProt Protein Name:	Staphylococcal nuclease domain-containing protein 1
UniProt Synonym Protein Names:	100 kDa coactivator; EBNA2 coactivator p100; Tudor domain-containing protein 11; p100 co-activator
Protein Family:	Staphylococcal nuclease domain-containing protein
UniProt Gene Name:	SND1
UniProt Entry Name:	SND1_HUMAN

	Western blot analysis of extracts of various cell lines, using SND1 antibody (CAB5874) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
	Western blot analysis of extracts from normal (control) and SND1 Rabbit pAb knockout (KO) HeLa cells, using SND1 Rabbit pAb antibody (CAB5874) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
	Immunohistochemistry of paraffin-embedded Mouse kidney using SND1 Rabbit pAb (CAB5874) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded Rat lung using SND1 Rabbit pAb (CAB5874) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded Human colon using SND1 Rabbit pAb (CAB5874) at dilution of 1:100 (40x lens).