Cell Biology Antibodies 4

Anti-SNAP23 Antibody (CAB13909)

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SKU:
CAB13909
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-SNAP23 Antibody
Antibody SKU:CAB13909
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-211 of human SNAP23 (NP_003816.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:100 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-211 of human SNAP23 (NP_003816.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDNL SSEE IQQR AHQI TDES LEST RRIL GLAI ESQD AGIK TITM LDEQ KEQL NRIE EGLD QINK DMRE TEKT LTEL NKCC GLCV CPCN RTKN FESG KAYK TTWG DGGE NSPC NVVS KQPG PVTN GQLQ QPTT GAAS GGYI KRIT NDAR EDEM EENL TQVG SILG NLKD MALN IGNE IDAQ NPQI KRIT DKAD TNRD RIDI ANAR AKKL IDS
Gene ID:8773
Uniprot:O00161
Cellular Location:Cell junction, Cell membrane, Lipid-anchor, Peripheral membrane protein, synapse, synaptosome
Calculated MW:17kDa/23kDa
Observed MW:23kDa
Synonyms:SNAP23, HsT17016, SNAP-23, SNAP23A, SNAP23B
Background:Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene.
UniProt Protein Function:SNAP23: a member of the SNAP-25 family of SNARE proteins. Structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:Vesicle

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: nucleoplasm; SNARE complex; azurophil granule; specific granule; neuron projection; mast cell granule; focal adhesion; cytoplasm; plasma membrane; synapse

Molecular Function:SNAP receptor activity; protein binding; syntaxin binding

Biological Process: synaptic vesicle fusion to presynaptic membrane; protein transport; histamine secretion by mast cell; vesicle targeting; post-Golgi vesicle-mediated transport; synaptic vesicle priming

NCBI Summary:Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:O00161
NCBI GenInfo Identifier:6685971
NCBI Gene ID:8773
NCBI Accession:O00161.1
UniProt Secondary Accession:O00161,O00162, Q13602, Q6IAE3,
UniProt Related Accession:O00161
Molecular Weight:17,789 Da
NCBI Full Name:Synaptosomal-associated protein 23
NCBI Synonym Full Names:synaptosomal-associated protein, 23kDa
NCBI Official Symbol:SNAP23  
NCBI Official Synonym Symbols:SNAP-23; SNAP23A; SNAP23B; HsT17016  
NCBI Protein Information:synaptosomal-associated protein 23; synaptosomal-associated protein, 23kD; vesicle-membrane fusion protein SNAP-23
UniProt Protein Name:Synaptosomal-associated protein 23
UniProt Synonym Protein Names:Vesicle-membrane fusion protein SNAP-23
Protein Family:Synaptosomal-associated protein
UniProt Gene Name:SNAP23  
UniProt Entry Name:SNP23_HUMAN
Anti-SNAP23 Antibody (CAB13909)Western blot analysis of extracts of various cell lines, using SNAP23 antibody (CAB13909) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 2min.
Anti-SNAP23 Antibody (CAB13909)Immunohistochemistry of paraffin-embedded rat lymph node using SNAP23 antibody (CAB13909) at dilution of 1:100 (40x lens).
Anti-SNAP23 Antibody (CAB13909)Immunohistochemistry of paraffin-embedded human appendix using SNAP23 antibody (CAB13909) at dilution of 1:100 (40x lens).
Anti-SNAP23 Antibody (CAB13909)Immunohistochemistry of paraffin-embedded mouse spleen using SNAP23 antibody (CAB13909) at dilution of 1:100 (40x lens).
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