Anti-SMYD3 Antibody (CAB2262)

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SKU:
CAB2262
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
KMT3E
Synonyms:
ZMYND1
Synonyms:
ZNFN3A1
Synonyms:
bA74P14.1
Research Area:
Cell Biology

Description

Product Name:SMYD3 Rabbit mAb
Product Code:CAB2262
Size:20uL, 50uL, 100uL
Synonyms:KMT3E, ZMYND1, ZNFN3A1, bA74P14.1
Applications:WB, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human SMYD3
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HCT116, MCF7, Mouse thymus, Rat brain
Immunogen:A synthesized peptide derived from human SMYD3
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:64754
Uniprot:Q9H7B4
Calculated MW:42kDa
Observed MW:42kDa
UniProt Protein Function:SMYD3: Histone methyltransferase. Specifically methylates 'Lys- 4' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences. Belongs to the histone-lysine methyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 2.1.1.43; Methyltransferase, protein lysine; Methyltransferase

Chromosomal Location of Human Ortholog: 1q44

Cellular Component: nucleoplasm; cytoplasm

Molecular Function:metal ion binding; histone-lysine N-methyltransferase activity

Biological Process: nucleosome assembly; establishment and/or maintenance of chromatin architecture; establishment of protein localization; myotube cell development; negative regulation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of peptidyl-serine phosphorylation

NCBI Summary:This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
UniProt Code:Q9H7B4
NCBI GenInfo Identifier:212276523
NCBI Gene ID:64754
NCBI Accession:Q9H7B4.4
UniProt Secondary Accession:Q9H7B4,Q86TL8, Q8N5Z6, Q96AI5, A8K0P0, B1AN38,
UniProt Related Accession:Q9H7B4
Molecular Weight:428
NCBI Full Name:Histone-lysine N-methyltransferase SMYD3
NCBI Synonym Full Names:SET and MYND domain containing 3
NCBI Official Symbol:SMYD3  
NCBI Official Synonym Symbols:KMT3E; ZMYND1; ZNFN3A1; bA74P14.1  
NCBI Protein Information:histone-lysine N-methyltransferase SMYD3; bA74P14.1 (novel protein); zinc finger, MYND domain containing 1; SET and MYND domain-containing protein 3; zinc finger MYND domain-containing protein 1; zinc finger protein, subfamily 3A (MYND domain containing)
UniProt Protein Name:Histone-lysine N-methyltransferase SMYD3
UniProt Synonym Protein Names:SET and MYND domain-containing protein 3; Zinc finger MYND domain-containing protein 1
Protein Family:Histone-lysine N-methyltransferase
UniProt Gene Name:SMYD3  
UniProt Entry Name:SMYD3_HUMAN
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